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A comparative investigation on the in vitro anti-inflammatory, antioxidant and antimicrobial potentials of subextracts from the aerial parts of Daphne oleoides Schreb. subsp oleoides

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dc.contributor.authorTAŞKIN, TURGUT
dc.contributor.authorsBalkan, Irem Atay; Taskin, Turgut; Dogan, Hacer Tugba; Deniz, Inci; Akaydin, Galip; Yesilada, Erdem
dc.date.accessioned2022-03-12T22:23:56Z
dc.date.available2022-03-12T22:23:56Z
dc.date.issued2017
dc.description.abstractDaphne oleoides Schreb. subsp. oleoides is an evergreen shrub which is known for its folkloric usage against various ailments such as arthritic and infectious diseases. The aim of the present study was to comparatively investigate the in vitro anti-inflammatory (nitric oxide inhibitory effects), antioxidant (DPPH center dot,ABTS(center dot+) and FRAP tests) and antimicrobial activities of the extract/subextracts from the aerial parts of D. oleoides Schreb. subsp. oleoides (Thymelaeaceae). The powdered aerial parts were first extracted with methanol and then partitioned into five subextracts (n-hexane, dichloromethane (CH2Cl2), ethyl acetate (EtOAC), n-butanol and remaining water) by succesive solvent extractions. The chemical compositions of the extracts were compared with regard to their total phenolic, total flavonoid contents and fatty acid compositions. The CH2Cl2 and n-hexane extracts exerted the highest inhibitory effect on NO production (61.67 +/- 13.97% inhibition at 50 mu g/ml and 67.91 +/- 11.17% inhibition at 100 mu g/ml, respectively) of LPS-induced Raw 264.7 cells. The EtOAC subextract showed the highest antioxidant effect evaluated by DPPH center dot (IC50: 0.35 +/- 0.12 mg/ml) and FRAP (4.54 +/- 10.01 mM FeSO4/mg extract) tests. The CH2Cl2 subextract was shown to contain the highest levels of flavonoids (0.837 +/- 10.035 mg QUE/mg extract) and was also found to be rich in phenolics (1.063 +/- 10.011 mg GAE/mg extract). Fatty acid analysis of the n-hexane extract revealed hexadecahoic acid and 9,15-octodecadienoic acids to be the major components. The n-hexane and CH2Cl2 subextracts exerted the'highest antimicrobial potential. (C) 2016 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.indcrop.2016.11.038
dc.identifier.eissn1872-633X
dc.identifier.issn0926-6690
dc.identifier.urihttps://hdl.handle.net/11424/234620
dc.identifier.wosWOS:000390621600079
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDaphne oleoides subsp oleoides
dc.subjectAnti-inflammatory
dc.subjectAntioxidant
dc.subjectAntimicrobial
dc.subjectPhenolics
dc.subjectFatty acids
dc.subjectFOLK MEDICINE
dc.subjectTRADITIONAL MEDICINE
dc.subjectINFLAMMATORY RESPONSES
dc.subjectNATURAL ANTIOXIDANTS
dc.subjectGUIDED ISOLATION
dc.subjectNITRIC-OXIDE
dc.subjectPONTICA L.
dc.subjectFLAVONOIDS
dc.subjectTURKEY
dc.subjectCYTOKINES
dc.titleA comparative investigation on the in vitro anti-inflammatory, antioxidant and antimicrobial potentials of subextracts from the aerial parts of Daphne oleoides Schreb. subsp oleoides
dc.typearticle
dspace.entity.typePublication
local.avesis.id1a5dff57-45cc-48ea-8dc2-9510beb2653a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
local.journal.quartileQ1
oaire.citation.endPage703
oaire.citation.startPage695
oaire.citation.titleINDUSTRIAL CROPS AND PRODUCTS
oaire.citation.volume95
relation.isAuthorOfPublication265414e9-485c-42b8-903a-c467f6b49b84
relation.isAuthorOfPublication.latestForDiscovery265414e9-485c-42b8-903a-c467f6b49b84

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