Publication:
Determinants of low bone mineral density in premenopausal polycystic ovary syndrome patients

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dc.contributor.authorYOLDEMİR, AHMET TEVFİK
dc.contributor.authorsKaradag, Cihan; Yoldemir, Tevfik; Yavuz, Dilek Gogas
dc.date.accessioned2022-03-12T20:31:21Z
dc.date.available2022-03-12T20:31:21Z
dc.date.issued2017
dc.description.abstractObjective: The aim of this study was to evaluate the bone mineral density (BMD) values and to determine the associations between BMD and insulin sensitivity, hyperandrogenemia, body mass index (BMI), and sex hormones in premenopausal polycystic ovary syndrome (PCOS) patients. Methods: A hundred and three women with PCOS and sixty age- and BMI-matched healthy control women were enrolled to this cross-sectional study. Serum androgen and estradiol (E2) levels were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) and MATSUDA insulin sensitivity index (ISI) were calculated. BMD was measured with a dual X-ray absorptiometer. Results: Lumbar BMD (LBMD) and femoral neck BMD (FnBMD) values were significantly lower in PCOS group than controls [(p<0.01) and (p<0.01)]. In PCOS group, hyperandrogenemic women had higher LBMD and FnBMD values than normoandrogenemic PCOS patients [(p<0.01) and (p<0.01)]. In PCOS group, LBMD was significantly correlated with HOMA-IR (r=0.617; p<0.01), MATSUDA ISI (r=-0.665; p<0.01), serum E2 (r=0.488; p<0.01), total testosterone (r=0.436; p<0.01), and androstenedione (r=0.337; p<0.01) levels. Similar correlations observed for FnBMD. Conclusions: Despite the positive effects of hyperandrogenemia and hyperinsulinemia, PCOS patients have lower bone mineral density due to hypoestrogenism. Insulin resistance, BMI, estrogen, and androgen levels are the determinants of BMD in PCOS.
dc.identifier.doi10.1080/09513590.2016.1250256
dc.identifier.eissn1473-0766
dc.identifier.issn0951-3590
dc.identifier.pubmed27908213
dc.identifier.urihttps://hdl.handle.net/11424/234279
dc.identifier.wosWOS:000399504300014
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofGYNECOLOGICAL ENDOCRINOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBone mineral density
dc.subjectHOMA-IR
dc.subjecthyperandrogenemia
dc.subjectMATSUDA
dc.subjectpolycystic ovary syndrome
dc.subjectINSULIN-RESISTANCE
dc.subjectTESTOSTERONE LEVELS
dc.subjectBODY-COMPOSITION
dc.subjectLEAN WOMEN
dc.subjectHYPERINSULINEMIA
dc.subjectSENSITIVITY
dc.subjectHIRSUTISM
dc.titleDeterminants of low bone mineral density in premenopausal polycystic ovary syndrome patients
dc.typearticle
dspace.entity.typePublication
local.avesis.idfba053ce-6399-4590-8cac-233e74d93053
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages4
local.journal.quartileQ4
oaire.citation.endPage237
oaire.citation.issue3
oaire.citation.startPage234
oaire.citation.titleGYNECOLOGICAL ENDOCRINOLOGY
oaire.citation.volume33
relation.isAuthorOfPublicationa83f8663-e08c-4cde-a28b-fbd444a689e0
relation.isAuthorOfPublication.latestForDiscoverya83f8663-e08c-4cde-a28b-fbd444a689e0

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