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Ginkgo biloba extract improves oxidative organ damage in a rat model of thermal trauma

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsSakarcan, A; Sehirli, O; Velioglu-Ovunc, A; Ercan, F; Erkanli, G; Gedik, N; Sener, G
dc.date.accessioned2022-03-12T17:21:44Z
dc.date.available2022-03-12T17:21:44Z
dc.date.issued2005
dc.description.abstractThis study was designed to determine the possible protective effect of Ginkgo biloba extract (EGb) against oxidative organ damage distant from the original burn wound. Under brief ether anesthesia, the shaved dorsum of the rats was exposed to 90 degrees C (burn group) or 25 degrees C (control group) water bath for 10 seconds. EGb (50 mg/kg/day) or saline was administered intraperitoneally immediately and at 12 hours after the burn injury. Rats were decapitated 24 hours after burn injury and tissue samples from the liver and kidney were taken for the determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, and collagen contents. Formation of reactive oxygen species in the tissue samples was monitored by the chemiluminescence technique. Tissues also were examined microscopically. Blood urea nitrogen, creatinine, alanine aminotransferase, and aspartate aminotransferase levels and tumor necrosis factor- and lactate dehydrogenase activity were assayed in serum samples. Severe skin scald injury (30% TBSA) caused a significant decrease in GSH levels and significant increases in MDA levels, MPO activity, and collagen content of hepatic and renal tissues. Treatment of rats with EGb significantly increased the GSH level and decreased the MDA level, MPO activity, and collagen contents. Similarly, serum alanine aminotransferase, aspartate aminotransferase, and blood urea nitrogen levels, as well as lactate dehydrogenase and tumor necrosis factor-, were increased in the burn group as compared with the control group. However, treatment with EGb reversed all these biochemical indices, as well as histopathological alterations that were induced by thermal trauma. Our results show that thermal trauma-induced oxidative damage in hepatic and renal tissues is protected by the administration of EGb, with its antioxidant effects. Therefore, its therapeutic role as a tissue injury-limiting agent must be further elucidated in oxidant-induced tissue damage.
dc.identifier.doi10.1097/01.bcr.0000185115.17261.50
dc.identifier.issn0273-8481
dc.identifier.pubmed16278567
dc.identifier.urihttps://hdl.handle.net/11424/228359
dc.identifier.wosWOS:000233396800010
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofJOURNAL OF BURN CARE & REHABILITATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLIPID-PEROXIDATION
dc.subjectFREE-RADICALS
dc.subjectEGB 761
dc.subjectANTIOXIDANT THERAPY
dc.subjectREACTIVE OXYGEN
dc.subjectNITRIC-OXIDE
dc.subjectBURN TRAUMA
dc.subjectIN-VIVO
dc.subjectINJURY
dc.subjectINFLAMMATION
dc.titleGinkgo biloba extract improves oxidative organ damage in a rat model of thermal trauma
dc.typearticle
dspace.entity.typePublication
local.avesis.id6d7ab3a8-ac67-494e-9d94-0fad4c7b3ac5
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages10
oaire.citation.endPage524
oaire.citation.issue6
oaire.citation.startPage515
oaire.citation.titleJOURNAL OF BURN CARE & REHABILITATION
oaire.citation.volume26
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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