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The effect of PCOS status on atherosclerosis markers and cardiovascular disease risk factors in young women with vitamin D deficiency

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dc.contributor.authorYOLDEMİR, AHMET TEVFİK
dc.contributor.authorsAtasayan, Kemal; Yoldemir, Tevfik
dc.date.accessioned2022-03-12T22:42:41Z
dc.date.available2022-03-12T22:42:41Z
dc.date.issued2021
dc.description.abstractObjective To investigate whether polycystic ovary syndrome (PCOS) had further deteriorating influence on endothelial function or cardiometabolic parameters in women with vitamin D deficiency during reproductive age. Study design The study group was composed of women with PCOS and vitamin D deficiency and insufficiency between the ages of 18 and 35 years. Age and body mass index (BMI)-matched women were chosen as controls. Serum 25(OH) Vit D levels below 20 ng/mL were considered as vitamin D deficiency. The cutoff level of vitamin D insufficiency was suggested at 30 ng/mL. Serum FSH, LH, estradiol, testosterone, DHEA-S, fasting glucose, total cholesterol, HDL, LDL, triglyceride levels were analyzed. Carotid artery intima-media thickness (CIMT) was measured, and the flow-mediated vasodilation (FMD) was calculated. Results CIMT and FMD values in both vitamin D deficiency and insufficiency subgroups showed no significant difference between PCOS and non-PCOS groups. There was a weak negative correlation between BMI, waist/hip ratio, CRP, and 25(OH) Vitamin D. Conclusion PCOS is a heterogeneous disease with different combinations of the diagnostic components. Vitamin D is an important variable for a healthy cardiovascular system. We did not find any difference in early atherosclerotic markers and cardiometabolic features between PCOS and non-PCOS group with Vitamin D deficiency.
dc.identifier.doi10.1080/09513590.2020.1826428
dc.identifier.eissn1473-0766
dc.identifier.issn0951-3590
dc.identifier.pubmed32996333
dc.identifier.urihttps://hdl.handle.net/11424/236250
dc.identifier.wosWOS:000573983100001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofGYNECOLOGICAL ENDOCRINOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPCOS
dc.subjectvitamin D deficiency
dc.subjectvitamin D insufficiency
dc.subjectCIMT
dc.subjectFMD
dc.subjectPOLYCYSTIC-OVARY-SYNDROME
dc.subjectENDOTHELIAL FUNCTION
dc.subjectINSULIN-RESISTANCE
dc.subjectD SUPPLEMENTATION
dc.subjectMETABOLIC DISTURBANCES
dc.subjectANDROGEN LEVELS
dc.subjectMETAANALYSIS
dc.subjectDIAGNOSIS
dc.titleThe effect of PCOS status on atherosclerosis markers and cardiovascular disease risk factors in young women with vitamin D deficiency
dc.typearticle
dspace.entity.typePublication
local.avesis.id0c569fea-0169-4b54-aef4-a250916c1448
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
local.journal.quartileQ3
oaire.citation.endPage229
oaire.citation.issue3
oaire.citation.startPage225
oaire.citation.titleGYNECOLOGICAL ENDOCRINOLOGY
oaire.citation.volume37
relation.isAuthorOfPublicationa83f8663-e08c-4cde-a28b-fbd444a689e0
relation.isAuthorOfPublication.latestForDiscoverya83f8663-e08c-4cde-a28b-fbd444a689e0

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