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Obstetric outcomes of recurrent pregnancy loss patients diagnosed with inherited thrombophilia

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dc.contributor.authorYOLDEMİR, AHMET TEVFİK
dc.contributor.authorsKaradag, C.; Yoldemir, T.; Karadag, S. D.; Inan, C.; Dolgun, Z. N.; Aslanova, L.
dc.date.accessioned2022-03-12T22:23:52Z
dc.date.available2022-03-12T22:23:52Z
dc.date.issued2017
dc.description.abstractBackground Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies. The relation between RPL and inherited thrombophilia requires anticoagulant therapy during pregnancy. However the obstetric outcomes have not been well defined in these RPL patients diagnosed with inherited thrombophilia, who have been given anticoagulant therapy. Aim To investigate the obstetric outcomes in pregnant women with RPL who are given low molecular weight heparin (LMWH) and low-dose aspirin due to diagnosis of inherited thrombophilia. Methods A hundred and eight RPL women were diagnosed with inherited thrombophilia, and 98 women were diagnosed with unexplained RPL. The patients with inherited thrombophilia were given LMWH and low-dose aspirin. Unexplained RPL patients were not given any medicine. The obstetric outcomes of participants were noted. Results In thrombophilic group, the live-birth levels were significantly higher [90 (83%) vs 67 (68%) p < 0.05], and the miscarriage levels were significantly lower than that in the control group [14 (13%) vs 27 (28%) p < 0.01]. The number of patients with preeclampsia was significantly higher in the thrombophilic group [16 (15%) vs 6 (6%) p < 0.05]. The number of preterm births was significantly higher than that of the controls [25 (23%) vs 10 (10%) p < 0.05]. The median gestation age of delivery was 35 weeks for thrombophilic patients and 38 weeks for controls (p < 0.05). Conclusion The RPL patients diagnosed with inherited thrombophilia and who were given LMWH with low-dose aspirin had higher live-birth rates and lower miscarriage rates than those in the unexplained RPL patients. Increased risk of preeclampsia is seen in RPL patients with inherited thrombophilia despite thrombophilia prophylaxis.
dc.identifier.doi10.1007/s11845-017-1569-0
dc.identifier.eissn1863-4362
dc.identifier.issn0021-1265
dc.identifier.pubmed28176193
dc.identifier.urihttps://hdl.handle.net/11424/234592
dc.identifier.wosWOS:000407372800026
dc.language.isoeng
dc.publisherSPRINGER LONDON LTD
dc.relation.ispartofIRISH JOURNAL OF MEDICAL SCIENCE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRecurrent pregnancy loss
dc.subjectInherited thrombophilia
dc.subjectLow molecular weight heparin
dc.subjectPreeclampsia
dc.subjectAspirin
dc.subjectMOLECULAR-WEIGHT HEPARIN
dc.subjectFACTOR-V-LEIDEN
dc.subjectRISK-FACTORS
dc.subjectFETAL LOSS
dc.subjectWOMEN
dc.subjectPREECLAMPSIA
dc.subjectCOMPLICATIONS
dc.subjectASSOCIATION
dc.subjectMETAANALYSIS
dc.subjectPROTHROMBIN
dc.titleObstetric outcomes of recurrent pregnancy loss patients diagnosed with inherited thrombophilia
dc.typearticle
dspace.entity.typePublication
local.avesis.id7da434ea-6b18-436c-a40b-a88128ce950d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ3
oaire.citation.endPage713
oaire.citation.issue3
oaire.citation.startPage707
oaire.citation.titleIRISH JOURNAL OF MEDICAL SCIENCE
oaire.citation.volume186
relation.isAuthorOfPublicationa83f8663-e08c-4cde-a28b-fbd444a689e0
relation.isAuthorOfPublication.latestForDiscoverya83f8663-e08c-4cde-a28b-fbd444a689e0

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