Publication:
Production of 3D-Printed Tympanic Membrane Scaffolds as a Tissue Engineering Application

Simple item page
dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsIlhan E., Ulag S., Sahin A., Ekren N., Kilic O., Oktar F.N., Gunduz O.
dc.date.accessioned2022-03-15T02:15:53Z
dc.date.available2022-03-15T02:15:53Z
dc.date.issued2020
dc.description.abstractIn recent years, scaffolds produced in 3D printing technology have become more widespread tool due to providing more advantages than traditional methods in tissue engineering applications. In this research, it was aimed to produce patches for the treatment of tympanic membrane perforations which caused significant hearing loss by using 3D printing method. Polylactic acid (PLA) scaffolds with Chitosan (CS) added in various ratios were prepared for artificial eardrum patches. Different amounts of CS added to PLA to obtain more biocompatible scaffolds. The created patches were designed by mimicking the thickness of the natural tympanic membrane thanks to the precision provided by the 3D printed method. The produced scaffolds were analyzed separately for physical, chemical, morphological, mechanical and biocompatibility properties. Human adipose tissue-derived mesenchymal stem cells (hAD-MSCs) were used for cell culture study to analyze the biocompatibility properties. 15 wt% PLA was chosen as the control group. Scaffold containing 3 wt% CS demonstrated significantly superior and favorable features in printing quality. The study continued with these two scaffolds (15PLA and 15PLA/3CS). This study showed that PLA and PLA/CS 3D printed scaffolds are a potential application for repairing tympanic membrane perforation. © Springer Nature Switzerland AG 2020.
dc.identifier.doi10.1007/978-3-030-45385-5_16
dc.identifier.isbn9783030453848
dc.identifier.issn3029743
dc.identifier.urihttps://hdl.handle.net/11424/248169
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3D printing
dc.subjectBiomaterials
dc.subjectTissue engineering
dc.subjectTympanic membrane patch
dc.titleProduction of 3D-Printed Tympanic Membrane Scaffolds as a Tissue Engineering Application
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.id2c4c98f5-e054-4a47-858a-c615f89e2fe8
local.conference.title8th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2020
local.import.packageSS21
local.import.sourceScopus
local.indexed.atSCOPUS
oaire.citation.endPage184
oaire.citation.startPage175
oaire.citation.titleLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
oaire.citation.volume12108 LNBI
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

Files

Collections

Research Outputs