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Neurophysiologic assessment of small fibre damage in chemotherapy-induced peripheral neuropathy

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dc.contributor.authorİŞAK, BARIŞ
dc.contributor.authorsIsak, Baris; Tankisi, Hatice; Pugdahl, Kirsten; Ventzel, Lise; Finnerup, Nanna Brix; Fuglsang-Frederiksen, Anders
dc.date.accessioned2022-03-12T22:56:58Z
dc.date.available2022-03-12T22:56:58Z
dc.date.issued2021
dc.description.abstractObjective: In patients with chemotherapy-induced peripheral neuropathy (CIPN), demonstration of small fibre (SF) damage is important to understand chronic late effects. Methods: Thirty patients having complaints compatible with possible CIPN following treatment with oxaliplatin or docetaxel were compared with 27 healthy subjects. All subjects were evaluated with quantitative sensory testing (QST) assessing SF function and laser evoked potentials (LEP). In addition, SF-damage was assessed using cutaneous silent periods evoked with electrical (El-CSP) and laser (Ls-CSP) stimuli. Results: For LEP, N2P2 amplitudes were significantly smaller in patients than controls in both upper (P = 0.007) and lower extremities (P = 0.002), and the N1 amplitude in upper extremities of patients were significantly smaller than in controls (P = 0.001). SF-QST, LEP, Ls-CSP, and El-CSP were abnormal in 10 (33.3%), 16 (53.3%), 19 (63.3%), and 24 (80%) of CIPN patients, respectively. Conclusions: In patients with possible CIPN, El-CSP and Ls-CSP were more often abnormal than LEP and QST. This is probably because El-CSP and Ls-CSP inform mainly about peripheral nociceptive fibres, while LEP and QST inform about peripheral and central nociceptive pathways together. Significance: LEP and QST are established methods to detect SF-damage. El- and Ls-CSP might help clinicians in diagnosing SF-damage. (C) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.clinph.2021.02.406
dc.identifier.eissn1872-8952
dc.identifier.issn1388-2457
dc.identifier.pubmed34034962
dc.identifier.urihttps://hdl.handle.net/11424/236982
dc.identifier.wosWOS:000674175200023
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofCLINICAL NEUROPHYSIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChemotherapy
dc.subjectSmall fibre
dc.subjectLaser
dc.subjectQuantitative sensory testing
dc.subjectCutaneous silent period
dc.subjectCUTANEOUS SILENT PERIOD
dc.subjectLASER EVOKED-POTENTIALS
dc.subjectSKIN TEMPERATURE
dc.subjectINFRARED-LASER
dc.subjectHAIRY SKIN
dc.subjectPAIN
dc.subjectSTIMULATION
dc.subjectAFFERENTS
dc.subjectABNORMALITIES
dc.subjectSENSITIZATION
dc.titleNeurophysiologic assessment of small fibre damage in chemotherapy-induced peripheral neuropathy
dc.typearticle
dspace.entity.typePublication
local.avesis.id8feeccf0-424d-4bf3-8327-92d3824b9f67
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage1956
oaire.citation.issue8
oaire.citation.startPage1947
oaire.citation.titleCLINICAL NEUROPHYSIOLOGY
oaire.citation.volume132
relation.isAuthorOfPublication3978eebd-304b-4af3-930c-2db9759c860d
relation.isAuthorOfPublication.latestForDiscovery3978eebd-304b-4af3-930c-2db9759c860d

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