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Prelimbic Cortex Deep Brain Stimulation Reduces Binge Size in a Chronic Binge Eating Rat Model

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsSarica, Can; Ozkan, Mazhar; Bay, Husniye Hacioglu; Sehirli, Umit; Onat, Filiz; Ziyal, M. Ibrahim
dc.date.accessioned2022-03-12T22:24:47Z
dc.date.available2022-03-12T22:24:47Z
dc.date.issued2018
dc.description.abstractBackground: Binge eating (BE) involves the consumption of a large amount of food in a short period of time and a loss of control during the binge episode. It is a key feature of the major subtypes of eating disorders like bulimia nervosa, BE disorder, anorexia nervosa binge/purge type. Alterations in the mesocorticolimbic pathway play a crucial role in its pathophysiology. Objectives: We hypothesized that BE rats receiving deep brain stimulation (DBS) in the prelimbic cortex, a functional analog of the dorsolateral prefrontal cortex in humans, would have a reduced binge size compared with those receiving sham stimulation. Methods: Eight male Sprague-Dawley rats were implanted with a DBS electrode in the left prelimbic cortex. A protocol which included limited access to a sweet-fat diet was used to achieve a chronic BE state in the rats. After reaching a stable binge size, each rat had undergone sham, low-frequency stimulation (60 Hz), and high-frequency (130 Hz) stimulation for 3 sessions each, and 2 consecutive treatments were separated by at least 2 empty sessions to allow a washout of the effects. A one-way ANOVA was used for the data analysis. Results: Low-frequency (60 Hz) stimulation of the prelimbic cortex significantly reduced the binge size compared to the sham stimulation (p < 0.0001). High-frequency DBS (130 Hz) had no significant influence on this behavior when compared to sham stimulation (p = 0.9). Conclusions: This study suggests that low-frequency prelimbic cortex stimulation in BE would be useful for correcting prefrontal hypofunction which is strongly associated with BE and addiction pathogenesis. (c) 2018 S. Karger AG, Basel.
dc.identifier.doi10.1159/000486965
dc.identifier.eissn1423-0372
dc.identifier.issn1011-6125
dc.identifier.pubmed29533964
dc.identifier.urihttps://hdl.handle.net/11424/234835
dc.identifier.wosWOS:000430116400004
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofSTEREOTACTIC AND FUNCTIONAL NEUROSURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDeep brain stimulation
dc.subjectPrelimbic cortex
dc.subjectBinge eating
dc.subjectRat model
dc.subjectPrefrontal cortex hypofunction
dc.subjectETHANOL-CONSUMPTION
dc.titlePrelimbic Cortex Deep Brain Stimulation Reduces Binge Size in a Chronic Binge Eating Rat Model
dc.typearticle
dspace.entity.typePublication
local.avesis.id69e7a124-738e-4e08-9da0-9dc26e421d18
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ2
oaire.citation.endPage39
oaire.citation.issue1
oaire.citation.startPage33
oaire.citation.titleSTEREOTACTIC AND FUNCTIONAL NEUROSURGERY
oaire.citation.volume96
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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