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Molecular characterization and risk factors for carbapenem-resistant Gram-negative bacilli colonization in children: emergence of NDM-producing Acinetobacter baumannii in a newborn intensive care unit in Turkey

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dc.contributor.authorKEPENEKLİ KADAYİFCİ, EDA
dc.contributor.authorsKaraaslan, A.; Soysal, A.; Gelmez, G. Altinkanat; Kadayifci, E. Kepenekli; Soyletir, G.; Bakir, M.
dc.date.accessioned2022-03-12T20:27:05Z
dc.date.available2022-03-12T20:27:05Z
dc.date.issued2016
dc.description.abstractBackground: Multidrug-resistant Gram-negative bacilli are responsible for more than 50% of healthcare-associated infections. Colonization dynamics, characteristics, and risk factor data for CR-GNB are scarce in children. Aim: To examine the molecular characteristics of, and risk factors for nosocomial colonization with, carbapenem-resistant Gram-negative bacilli (CR-GNB) in hospitalized paediatric patients in a tertiary university hospital's paediatric units in Turkey. Methods: A prospective case-control study was performed at a university hospital in Istanbul, Turkey. Findings: A total of 1840 rectal swab specimens were collected from all 762 hospitalized children between March 2013 and October 2013. Among them, 176 (23%) patients were colonized with CR-GNB. Of these, 72 (9%) patients were colonized with carbapenem-resistant Enterobacteriaceae, 138 (18%) with CR-non-fermenter Gram-negative bacilli (CR-NF) and 34 (4%) with both. The median CR-GNB colonization time was 10 days (range: 1-116). The median duration of rectal colonization with CR-GNB was 8 days (range: 1-160). NDM (31%) was the second most frequent carbapenemase identified in Acinetobacter baumannii isolates, and has not previously been detected in Turkey. All of the 17 patients colonized with NDM-producing A. baumannii were newborns in the neonatal intensive care unit. Independent risk factors for CR-GNB colonization were: age <1 year, nasogastric tube placement, presence of underlying chronic diseases, ampicillin usage, surgical intervention, and carbapenem use.
dc.identifier.doi10.1016/j.jhin.2015.09.011
dc.identifier.eissn1532-2939
dc.identifier.issn0195-6701
dc.identifier.pubmed26601601
dc.identifier.urihttps://hdl.handle.net/11424/233619
dc.identifier.wosWOS:000367619800014
dc.language.isoeng
dc.publisherW B SAUNDERS CO LTD
dc.relation.ispartofJOURNAL OF HOSPITAL INFECTION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcinetobacter baumannii
dc.subjectCarbapenem resistance
dc.subjectChildren
dc.subjectColonization
dc.subjectGram-negative bacilli
dc.subjectNDM
dc.subjectMETALLO-BETA-LACTAMASES
dc.subjectKLEBSIELLA-PNEUMONIAE
dc.subjectNOSOCOMIAL INFECTION
dc.subjectMULTIPLEX PCR
dc.subjectACQUISITION
dc.subjectENTEROBACTERIACEAE
dc.subjectGENES
dc.titleMolecular characterization and risk factors for carbapenem-resistant Gram-negative bacilli colonization in children: emergence of NDM-producing Acinetobacter baumannii in a newborn intensive care unit in Turkey
dc.typearticle
dspace.entity.typePublication
local.avesis.ide525c016-80ee-4ef1-83d3-ee83413aa656
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ2
oaire.citation.endPage72
oaire.citation.issue1
oaire.citation.startPage67
oaire.citation.titleJOURNAL OF HOSPITAL INFECTION
oaire.citation.volume92
relation.isAuthorOfPublicationb2936619-4301-4864-bd7e-10de0b997be0
relation.isAuthorOfPublication.latestForDiscoveryb2936619-4301-4864-bd7e-10de0b997be0

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