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Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are Predictors of Heart Failure

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dc.contributor.authorSARI, İBRAHİM
dc.contributor.authorsDurmus, Erdal; Kivrak, Tarik; Gerin, Fethullah; Sunbul, Murat; Sari, Ibrahim; Erdogan, Okan
dc.date.accessioned2022-03-14T11:06:50Z
dc.date.available2022-03-14T11:06:50Z
dc.date.issued2015
dc.description.abstractBackground: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are inflammatory markers used as prognostic factors in various diseases. Objectives: To compare the PLR and the NLR of heart failure (HF) patients with those of age-sex matched controls, to evaluate the predictive value of those markers in detecting HF, and to demonstrate the effect of NLR and PLR on mortality in HF patients during follow-up. Methods: This study included 56 HF patients and 40 controls without HF. All subjects underwent transthoracic echocardiography to evaluate cardiac functions. The NLR and the PLR were calculated as the ratio of neutrophil count to lymphocyte count and as the ratio of platelet count to lymphocyte count, respectively. All HF patients were followed after their discharge from the hospital to evaluate mortality, cerebrovascular events, and re-hospitalization. Results: The NLR and the PLR of HF patients were significantly higher compared to those of the controls (p < 0.01). There was an inverse correlation between the NLR and the left ventricular ejection fraction of the study population (r: -0.409, p < 0.001). The best cut-off value of NLR to predict HF was 3.0, with 86.3% sensitivity and 77.5% specificity, and the best cut-off value of PLR to predict HF was 137.3, with 70% sensitivity and 60% specificity. Only NLR was an independent predictor of mortality in HF patients. A cut-off value of 5.1 for NLR can predict death in HF patients with 75% sensitivity and 62% specificity during a 12.8-month follow-up period on average. Conclusions: NLR and PLR were higher in HF patients than in age-sex matched controls. However, NLR and PLR were not sufficient to establish a diagnosis of HF. NLR can be used to predict mortality during the follow-up of HF patients.
dc.identifier.doi10.5935/abc.20150126
dc.identifier.issn0066-782X
dc.identifier.pubmed26536980
dc.identifier.urihttps://hdl.handle.net/11424/245902
dc.identifier.wosWOS:000369437800009
dc.language.isoeng
dc.publisherARQUIVOS BRASILEIROS CARDIOLOGIA
dc.relation.ispartofARQUIVOS BRASILEIROS DE CARDIOLOGIA
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHeart Failure / blood
dc.subjectHeart Failure / diagnosis
dc.subjectMultivariate Analysis
dc.subjectNeutrophils / cytology
dc.subjectLeukocyte Count
dc.subjectLymphocyte Count
dc.subjectELEVATION MYOCARDIAL-INFARCTION
dc.subjectACUTE CORONARY SYNDROMES
dc.subjectPROGNOSTIC VALUE
dc.subjectMORTALITY
dc.subjectRISK
dc.subjectDISEASE
dc.subjectUTILITY
dc.subjectMYELOPEROXIDASE
dc.subjectINFLAMMATION
dc.subjectASSOCIATION
dc.titleNeutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are Predictors of Heart Failure
dc.typearticle
dspace.entity.typePublication
local.avesis.id906a9b55-d633-46a6-ac01-34f9f4050947
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage612
oaire.citation.issue6
oaire.citation.startPage606
oaire.citation.titleARQUIVOS BRASILEIROS DE CARDIOLOGIA
oaire.citation.volume105
relation.isAuthorOfPublication26c97c3b-389c-4a43-9329-8693aa3c3333
relation.isAuthorOfPublication.latestForDiscovery26c97c3b-389c-4a43-9329-8693aa3c3333

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