Publication: The effect of serum levetiracetam concentrations on therapeutic response and IL1-beta concentration in patients with epilepsy
dc.contributor.author | ONAT, FİLİZ | |
dc.contributor.authors | Gulcebi, Medine I.; Kendirli, Tansel; Turgan, Zehra Asik; Patsalos, Philip N.; Onat, Filiz Yilmaz | |
dc.date.accessioned | 2022-03-14T10:17:10Z | |
dc.date.available | 2022-03-14T10:17:10Z | |
dc.date.issued | 2018-12 | |
dc.description.abstract | Objective: Assessment of the relevance between serum drug concentration to its therapeutic response is a valid monitoring strategy for the clinical efficacy of antiepileptic drugs (AEDs). Levetiracetam (LEV) is a broad spectrum AED with a possible anti-inflammatory effect. We aimed to determine the relationship between LEV concentrations and its therapeutic response, and the effect of LEV on IL1-beta concentrations in patients with epilepsy. Methods: Patients on monotherapy (n = 7) or polytherapy (n = 15) with LEV for their seizures management were included. Blood samples of each patient were collected: just before LEV intake, 1 h, 2 h, 4 h and 8 h following the last dose. Serum LEV concentrations were measured by liquid chromatography mass spectrometry and IL1-beta concentrations by chemiluminescent immunometric assay. Concentration to dose (C/D) ratio values was used for analyses. LEV concentrations were compared between responders (<= 1 seizure/month) and non responders (> 1 seizure/month) and patients with or without adverse reactions. IL1-beta concentrations before and at 2 h following LEV ingestion were compared in order to detect the effect of the increase in serum LEV concentration on IL1-beta. Results: Although there was no change in LEV (C/D) ratio or LEV maximum concentration (Cmax)/D ratio of the responders and non-responders, the C/D ratio following 1 h of LEV intake (2.17 +/- 0.59 kg.day/L) and Cmax/D ratio (2.25 +/- 0.56 kg.day/L) in the patients with adverse effects was significantly higher than for the patients without adverse effects (1.09 +/- 0.12 kg.day/L and 1.49 +/- 0.14 kg.day/L respectively). A statistically significant decrease was found in the IL1-beta concentration to LEV (C/D) ratio with the increase in LEV concentration in patients on LEV monotherapy. Conclusion: The possible relationship between LEV Cmax and its therapeutic response or IL1-beta concentrations may be an importance indication of LEV antiepileptic efficacy. Consequently, monitoring LEV Cmax values may enhance LEV adherence because patients would be less likely to develop adverse effects. | |
dc.identifier.doi | 10.1016/j.eplepsyres.2018.09.015 | |
dc.identifier.eissn | 1872-6844 | |
dc.identifier.issn | 0920-1211 | |
dc.identifier.pubmed | 30326332 | |
dc.identifier.uri | https://hdl.handle.net/11424/244304 | |
dc.identifier.wos | WOS:000452567700003 | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE BV | |
dc.relation.ispartof | EPILEPSY RESEARCH | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Antiepileptic drugs | |
dc.subject | Seizure frequency | |
dc.subject | Adverse effect | |
dc.subject | Cytokine | |
dc.subject | ANTIEPILEPTIC DRUGS | |
dc.subject | ILAE-COMMISSION | |
dc.subject | CHILDREN | |
dc.subject | LAMOTRIGINE | |
dc.subject | EFFICACY | |
dc.title | The effect of serum levetiracetam concentrations on therapeutic response and IL1-beta concentration in patients with epilepsy | |
dc.type | article | |
dspace.entity.type | Publication | |
local.avesis.id | 95b54ee4-1bd9-42f9-a644-4ca7c2d8ebb9 | |
local.import.package | SS16 | |
local.indexed.at | WOS | |
local.indexed.at | SCOPUS | |
local.journal.numberofpages | 6 | |
local.journal.quartile | Q3 | |
oaire.citation.endPage | 22 | |
oaire.citation.startPage | 17 | |
oaire.citation.title | EPILEPSY RESEARCH | |
oaire.citation.volume | 148 | |
relation.isAuthorOfPublication | c359dea3-046f-4397-90d5-62e4bfc31869 | |
relation.isAuthorOfPublication.latestForDiscovery | c359dea3-046f-4397-90d5-62e4bfc31869 |
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