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Multisystem inflammatory syndrome in children associated with covid-19 in 101 cases from Turkey (Turk-MISC study)

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dc.contributor.authorKEPENEKLİ KADAYİFCİ, EDA
dc.contributor.authorYAKUT, NURHAYAT
dc.contributor.authorsYilmaz Ciftdogan D., Ekemen Keles Y., Karbuz A., ÇETİN B. Ş., Elmas Bozdemir S., KEPENEKLİ KADAYİFCİ E., Metin Akcan O., Ozer A., Erat T., Sutcu M., et al.
dc.date.accessioned2023-03-13T06:57:02Z
dc.date.available2023-03-13T06:57:02Z
dc.date.issued2022-06-01
dc.description.abstractAim Multisystem inflammatory syndrome in children (MIS-C) may cause shock and even death in children. The aim of this study is to describe the clinical features, laboratory characteristics and outcome of children diagnosed with MIS-C in 25 different hospitals in Turkey. Methods The retrospective study was conducted between 8 April and 28 October 2020 in 25 different hospitals from 17 cities. Data were collected from patients\" medical records using a standardised form. Clinical and laboratory characteristics and outcomes according to different age groups, gender and body mass index percentiles were compared using multivariate logistic regression analysis. Results The study comprised 101 patients, median age 7 years (interquartile range (IQR) 4.6-9.3); 51 (50.5%) were boys. Reverse-transcriptase polymerase chain reaction (PCR) assay was positive in 21/100 (21%) patients; 62/83 (74.6%) patients had positive serology for SARS-CoV-2. The predominant complaints were fever (100%), fatigue (n = 90, 89.1%), and gastrointestinal symptoms (n = 81, 80.2%). Serum C-reactive protein (in 101 patients, median 165 mg/L; range 112-228), erythrocyte sedimentation rate (73/84, median 53 mm/s; IQR 30-84) and procalcitonin levels (86/89, median 5 mu g/L; IQR 0.58-20.2) were elevated. Thirty-eight patients (37.6%) required admission to intensive care. Kawasaki disease (KD) was diagnosed in 70 (69.3%) patients, 40 of whom had classical KD. Most patients were treated with intravenous immunoglobulin (n = 92, 91%) and glucocorticoids (n = 59, 58.4%). Seven patients (6.9%) died. Conclusion The clinical spectrum of MIS-C is broad, but clinicians should consider MIS-C in the differential diagnosis when persistent fever, fatigue and gastrointestinal symptoms are prominent. Most patients diagnosed with MIS-C were previously healthy. Immunomodulatory treatment and supportive intensive care are important in the management of cases with MIS-C. Glucocorticoids and intravenous immunoglobulins are the most common immunomodulatory treatment options for MIS-C. Prompt diagnosis and prompt treatment are essential for optimal management.
dc.identifier.citationYilmaz Ciftdogan D., Ekemen Keles Y., Karbuz A., ÇETİN B. Ş., Elmas Bozdemir S., KEPENEKLİ KADAYİFCİ E., Metin Akcan O., Ozer A., Erat T., Sutcu M., et al., "Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)", JOURNAL OF PAEDIATRICS AND CHILD HEALTH, cilt.58, sa.6, ss.1069-1078, 2022
dc.identifier.doi10.1111/jpc.15913
dc.identifier.endpage1078
dc.identifier.issn1034-4810
dc.identifier.issue6
dc.identifier.startpage1069
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35199895/
dc.identifier.urihttps://hdl.handle.net/11424/287390
dc.identifier.volume58
dc.language.isoeng
dc.relation.ispartofJOURNAL OF PAEDIATRICS AND CHILD HEALTH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectChild Health and Diseases
dc.subjectPEDİATRİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPEDIATRICS
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectPediatrics
dc.subjectPediatrics, Perinatology and Child Health
dc.subjectchild
dc.subjectCOVID-19
dc.subjectKawasaki disease
dc.subjectMIS-C
dc.subjectshock
dc.subjectRECEPTOR
dc.subjectDISEASE
dc.subjectSARS
dc.subjectchild
dc.subjectCOVID-19
dc.subjectKawasaki disease
dc.subjectMIS-C
dc.subjectshock
dc.titleMultisystem inflammatory syndrome in children associated with covid-19 in 101 cases from Turkey (Turk-MISC study)
dc.typearticle
dspace.entity.typePublication
local.avesis.idfa56ec26-8d84-44cf-9c8c-eaec75138586
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscoveryb2936619-4301-4864-bd7e-10de0b997be0

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