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The diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) compared to C-reactive protein (CRP) and procalcitonin (PCT) in children with systemic inflammatory response syndrome (SIRS)

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dc.contributor.authorKEPENEKLİ KADAYİFCİ, EDA
dc.contributor.authorsSirinoglu, Melis; Soysal, Ahmet; Karaaslan, Ayse; Kadayifci, Eda Kepenekli; Yalindag-Ozturk, Nilufer; Cinel, Ismail; Yaman, Ali; Haklar, Goncagul; Sirikci, Onder; Turan, Serap; Gelmez, Gulsen Altinkanat; Soyletir, Guner; Bakir, Mustafa
dc.date.accessioned2022-03-12T20:30:55Z
dc.date.available2022-03-12T20:30:55Z
dc.date.issued2017
dc.description.abstractBackground: The aim of the present study was to determine the diagnostic and prognostic values of suPAR and to compare them to CRP and PCT in pediatric patients with systemic inflammatory response syndrome (SIRS). Material-methods: A prospective case-control study was performed. The study was performed in a tertiary university hospital which has a 649-bed capacity. Patients included 27 children with SIRS and 27 control subjects without any infection or immunosuppressive condition. Blood samples were obtained on the day of admission and on the 4-7th days of the hospital stay. Results: The median (minemax) serum levels of suPAR obtained on the first day of the admission were 10.06 (2.7-57.46) and 2.22 (1.08-5.13) ng/Ml for the SIRS group and control group, respectively. The median serum levels of suPAR in the SIRS group was significantly higher than that in the control group (p < 0.05). The serum suPAR levels was significantly higher in nonsurvivors than in survivors in SIRS group (p < 0.05). In the SIRS group, the area under the receiver operating characteristics curve (AUC(ROC)) for suPAR revealed an optimum cut-off value, sensitivity, specificity, NPV and PPV of 0.978, 3.8 ng/mL, 96%, 96%, 96%, and 96%, respectively. Conclusions: We conclude that suPAR does have diagnostic value in children with SIRS. Additionally, persistent high serum suPAR level predicts mortality in SIRS in children. (C) 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.jiac.2016.08.015
dc.identifier.eissn1437-7780
dc.identifier.issn1341-321X
dc.identifier.pubmed27771157
dc.identifier.urihttps://hdl.handle.net/11424/234227
dc.identifier.wosWOS:000396443100003
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofJOURNAL OF INFECTION AND CHEMOTHERAPY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSoluble urokinase plasminogen activator receptor
dc.subjectSIRS
dc.subjectChildren
dc.subjectPREDICTS MORTALITY
dc.subjectLEVEL
dc.titleThe diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) compared to C-reactive protein (CRP) and procalcitonin (PCT) in children with systemic inflammatory response syndrome (SIRS)
dc.typearticle
dspace.entity.typePublication
local.avesis.id9bcd5b4a-e4f4-4409-b418-2659e7b0a738
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ4
oaire.citation.endPage22
oaire.citation.issue1
oaire.citation.startPage17
oaire.citation.titleJOURNAL OF INFECTION AND CHEMOTHERAPY
oaire.citation.volume23
relation.isAuthorOfPublicationb2936619-4301-4864-bd7e-10de0b997be0
relation.isAuthorOfPublication.latestForDiscoveryb2936619-4301-4864-bd7e-10de0b997be0

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