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Clinical and functional impact of central sensitization on patients with familial Mediterranean fever: a cross-sectional study

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dc.contributor.authorYÜCEL, FEYZA NUR
dc.contributor.authorGEZER, HALİSE HANDE
dc.contributor.authorÖZ, NURAN
dc.contributor.authorACER KASMAN, SEVTAP
dc.contributor.authorDURUÖZ, MEHMET TUNCAY
dc.contributor.authorsYÜCEL F. N. , Gezer H. H. , Jandaulyet J., Oz N., Acer Kasman S., DURUÖZ M. T.
dc.date.accessioned2022-10-04T12:04:31Z
dc.date.available2022-10-04T12:04:31Z
dc.date.issued2022-08-01
dc.description.abstractThis study aimed to investigate the frequency of CS and its clinical and functional effects on familial Mediterranean fever (FMF). A hundred FMF patients were included in this study. The presence of CS was investigated by the central sensitization inventory (CSI). In addition to the detailed clinical features of patients and genetic mutations, quality of life, disability, sleep disorders, depression, anxiety, and fibromyalgia frequency were examined to evaluate the negative effects of CS on the individual. Patients were divided into groups according to the presence and severity of CS, and their results were compared. Correlation and multivariate regression analysis were performed to investigate the association of CS with selected demographic and clinical parameters. The mean CSI was 37.72 (SD: 19.35), and thirty-eight (38%) patients had CS. Sacroiliitis occurred in 11 patients (11%), amyloidosis in 3 (3%), and erysipelas-like erythema in 11 (11%). The most prevalent genetic mutation was M694/any compound heterogeneous (35.7%), followed by M69V homogeneous (30%). Regarding comparing the patients with and without CS, the number of attacks, disease activity, daily colchicine dose, and all investigated comorbidities were significantly higher in the patients with CS (p < 0.05). In regression analysis, gender, colchicine dose and sleep disturbance were detected as related parameters with CS (OR (95% CI): 6.05 (1.39; 26.32), p: 0.017, OR (95% CI): 6.69 (1.65; 27.18), p: 0.008, OR (95% CI): 1.35 (1.35; 1.59), p: 0.001, respectively). Concomitant pain sensitization appears to be related to FMF patients\" clinical and functional characteristics. These results suggest taking into consideration CS in the management of FMF patients.
dc.identifier.citationYÜCEL F. N. , Gezer H. H. , Jandaulyet J., Oz N., Acer Kasman S., DURUÖZ M. T. , "Clinical and functional impact of central sensitization on patients with familial Mediterranean fever: a cross-sectional study", RHEUMATOLOGY INTERNATIONAL, 2022
dc.identifier.doi10.1007/s00296-022-05181-6
dc.identifier.issn0172-8172
dc.identifier.urihttps://hdl.handle.net/11424/282099
dc.language.isoeng
dc.relation.ispartofRHEUMATOLOGY INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectImmunology and Rheumatology
dc.subjectHealth Sciences
dc.subjectROMATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectRHEUMATOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectRomatoloji
dc.subjectRheumatology
dc.subjectCentral sensitization
dc.subjectCentral sensitization inventory
dc.subjectFamilial Mediterranean fever
dc.subjectİnflammation
dc.titleClinical and functional impact of central sensitization on patients with familial Mediterranean fever: a cross-sectional study
dc.typearticle
dspace.entity.typePublication
local.avesis.ida5494781-eb76-4ef6-8a78-94a90578e782
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscovery52ef0381-a8ea-42ea-9031-a35a2fcc7b1e

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