Publication:
Effect of hyperbaric oxygen therapy on cerebral vasospasm: a vascular morphometric study in an experimental subarachnoid hemorrhage model

Simple item page
dc.contributor.authorZİYAL, MUSTAFA İBRAHİM
dc.contributor.authorsCelik, Ozgur; Bay, Husniye Hacioglu; Arslanhan, Ayca; Oroglu, Bengusu; Bozkurt, Suheyla Uyar; Sehirli, Umit Suleyman; Ziyal, Mustafa Ibrahim
dc.date.accessioned2022-03-13T12:45:33Z
dc.date.available2022-03-13T12:45:33Z
dc.date.issued2014
dc.description.abstractThis study was undertaken to investigate the preventive or therapeutic effect of hyperbaric oxygen therapy (HBOT) on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH). Twenty rabbits were assigned randomly to one of four groups. Animals in Group I were not subjected to SAH or sham operation (control group, n = 5). Animals in Group II were subjected to sham operation and received no treatment after the procedure (sham group, n = 5). Animals in Group III were subjected to SAH and received no treatment after SAH induction (SAH group, n = 5). Animals in Group IV were subjected to SAH and received five sessions of HBOT at 2.4 atmospheres absolute (ATA) for 2 h (treatment group, n = 5). Animals were euthanized by perfusion and fixation 72 h after procedures. Basilar artery vasospasm indices, arterial wall thicknesses, and cross-sectional luminal areas were evaluated. Statistical comparisons were performed using Kruskal-Wallis and Mann-Whitney U tests. Mean basilar artery vasospasm index in the treatment group was significantly smaller than in the SAH group. Mean basilar artery wall thickness in the treatment group was significantly smaller than in the SAH group. Mean basilar artery cross-sectional luminal area in the treatment group showed an increase relative to the SAH group, but this difference remained statistically insignificant. Our results demonstrated that repeated application of HBOT at 2.4 ATA for 2 h attenuated vasospastic changes such as increased vasospasm index and arterial wall thickness. HBOT is thus a promising candidate for SAH-induced vasospasm. Further studies are needed to evaluate maximal effect and optimal application regimen.
dc.identifier.doi10.3109/00207454.2013.865619
dc.identifier.eissn1563-5279
dc.identifier.issn0020-7454
dc.identifier.pubmed24228831
dc.identifier.urihttps://hdl.handle.net/11424/237801
dc.identifier.wosWOS:000339114700007
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF NEUROSCIENCE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCerebral vasospasm
dc.subjecthyperbaric oxygen
dc.subjectsubarachnoid hemorrhage
dc.subjectvascular morphometry
dc.subjectvasospasm index
dc.subjectwall thickness
dc.subjectINTERCELLULAR-ADHESION MOLECULE-1
dc.subjectMONOCLONAL-ANTIBODY
dc.subjectENDOTHELIAL-CELLS
dc.subjectRHOA/RHO-KINASE
dc.subjectBASILAR ARTERY
dc.subjectRAT MODEL
dc.subjectEXPRESSION
dc.subjectINFLAMMATION
dc.subjectISCHEMIA
dc.subjectAPOPTOSIS
dc.titleEffect of hyperbaric oxygen therapy on cerebral vasospasm: a vascular morphometric study in an experimental subarachnoid hemorrhage model
dc.typearticle
dspace.entity.typePublication
local.avesis.idf9f2d6c0-0cf0-46da-a71d-e6aaf304dbff
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage600
oaire.citation.issue8
oaire.citation.startPage593
oaire.citation.titleINTERNATIONAL JOURNAL OF NEUROSCIENCE
oaire.citation.volume124
relation.isAuthorOfPublication46a6b10d-eb37-4d57-bb42-06c6453cf890
relation.isAuthorOfPublication.latestForDiscovery46a6b10d-eb37-4d57-bb42-06c6453cf890

Files

Collections

Research Outputs