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Outcomes of Pediatric Fistulising Perianal Crohn's Disease

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dc.contributor.authorERTEM ŞAHİNOĞLU, DENİZ
dc.contributor.authorsAkkelle, Bilge S.; Sengul, Ozlem K.; Volkan, Burcu; Tutar, Engin; Ergelen, Rabia; Yardimci, Samet; Ertem, Deniz
dc.date.accessioned2022-03-12T22:55:29Z
dc.date.available2022-03-12T22:55:29Z
dc.date.issued2021
dc.description.abstractBackground: Perianal disease is reported more widely in pediatric Crohn patients than in the past, and hos been stated as an independent modifier of the disease behavior. In this study, we aimed to analyze the clinical characteristics and outcomes of fistulising perianal Crohn's disease (fpCD) in the pediatric age group. Methods: A total number of 149 children with an established diagnosis of inflammatory bowel disease who have been diagnosed before 18 years of age and followed in our tertiary center were revised. Clinical, endoscopic, laboratory, and radiologic data of 50 patients with CD, who had at least 18 months follow-up data, were compiled. Results: Of 50 patients, 26 (52%) were diagnosed as fpCD (38% at onset). More than half of the patients without any notable external orifices around the perianal area were diagnosed as fpCD by an magnetic resonance imaging (MRI). Pediatric fpCD patients hod a higher disease activity score and platelet count, lower serum albumin level, and a higher rate of granuloma in the biopsy samples, compared with non-fistulising patients. A considerably high rate of surgical interventions (i.e., seton placement 46% and abscess drainage 15%) was performed in combination with infiiximab. Conclusion: Fistulising perianal Crohn's disease seems to be more common than previously reported in the pediatric age group. A severe course of the disease might serve as a warning for the development of fpCD. A careful physical examination and use of perianal MRI with a high index of suspicion may increase the likelihood of fistula detection, hence may change the treatment strategy.
dc.identifier.doi10.5152/tjg.2021.191034
dc.identifier.eissn2148-5607
dc.identifier.pubmed34160353
dc.identifier.urihttps://hdl.handle.net/11424/236758
dc.identifier.wosWOS:000667494100002
dc.language.isoeng
dc.publisherAVES
dc.relation.ispartofTURKISH JOURNAL OF GASTROENTEROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPediatric
dc.subjectperianal fistulising Crohn's disease
dc.subjectseton
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectNATURAL-HISTORY
dc.subjectRISK-FACTORS
dc.subjectCHILDREN
dc.subjectDIAGNOSIS
dc.subjectGRANULOMAS
dc.subjectPHENOTYPE
dc.subjectCONSENSUS
dc.subjectONSET
dc.subjectCLASSIFICATION
dc.titleOutcomes of Pediatric Fistulising Perianal Crohn's Disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id9c5f98fc-2df1-469e-898d-bc474993d967
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage247
oaire.citation.issue3
oaire.citation.startPage240
oaire.citation.titleTURKISH JOURNAL OF GASTROENTEROLOGY
oaire.citation.volume32
relation.isAuthorOfPublicatione1f19d32-05e2-4206-864e-f3936b370d99
relation.isAuthorOfPublication.latestForDiscoverye1f19d32-05e2-4206-864e-f3936b370d99

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