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Topiramate and accommodation: Does topiramate cause accommodative dysfunction?

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dc.contributor.authorÇERMAN, EREN
dc.contributor.authorsCerman, Eren; Turhan, Semra Akkaya; Eraslan, Muhsin; Koytak, Pinar Kahraman; Kilinc, Ozden; Tanridag, Tlin
dc.date.accessioned2022-03-12T20:31:50Z
dc.date.available2022-03-12T20:31:50Z
dc.date.issued2017
dc.description.abstractObjective: To investigate the accommodation function in topiramate users. Design:Case-control clinical study. Participants:The participants included 16 controls and 22 patients using 100 mg/kg topiramate who were diagnosed with migraine according to the International Classification of Headache Disorders, second edition criteria. Methods:One-minute dynamic measurements of refraction with accommodation stimuli of 0 D, 2 D, 2.5 D, 3 D, 4 D, and 5 D were obtained using the open field refractometer WAM-5500 in. Results:In most of the accommodation stimuli ranges (0 D, 2.5 D, 3 D, and 5 D), topiramate users had a significantly higher accommodative lag compared with controls (p=0.028, p =0.014, p=0.011, and p=0.011, respectively). The most important causes of accommodative lag were found to be accommodation stimulus and inclusion in the topiramate group (p<0.001, R-2=0.32, 95% CI 0.22-0.37 and 0.42-0.91, respectively). Multivariate linear regression analysis revealed that the 2 most important predictors of accommodative lag were accommodation stimulus and age (p<0.001, r=0.51, 95% CI 0.31-0.32 and 0.67-0.69, respectively) CONCLUSIONS: Even after adjustment for age, accommodative lag is greater across several accommodative stimulus levels in patients using topiramate, which may be related to visual symptoms in topiramate users.
dc.identifier.doi10.1016/j.jcjo.2016.07.025
dc.identifier.eissn1715-3360
dc.identifier.issn0008-4182
dc.identifier.pubmed28237143
dc.identifier.urihttps://hdl.handle.net/11424/234333
dc.identifier.wosWOS:000396899600024
dc.language.isoeng
dc.publisherCANADIAN OPHTHAL SOC
dc.relation.ispartofCANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectANGLE-CLOSURE GLAUCOMA
dc.subjectDYNAMIC ACCOMMODATION
dc.subjectVISUAL DISCOMFORT
dc.subjectMYOPIC SHIFT
dc.subjectAGE
dc.subjectAUTOREFRACTOR
dc.subjectWAM-5500
dc.subjectLAG
dc.titleTopiramate and accommodation: Does topiramate cause accommodative dysfunction?
dc.typearticle
dspace.entity.typePublication
local.avesis.id12b2b649-7fba-4d7f-82f8-c0ae60566de0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ4
oaire.citation.endPage25
oaire.citation.issue1
oaire.citation.startPage20
oaire.citation.titleCANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
oaire.citation.volume52
relation.isAuthorOfPublication94b7eabe-feca-456f-8edb-62cf4425293a
relation.isAuthorOfPublication.latestForDiscovery94b7eabe-feca-456f-8edb-62cf4425293a

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