Publication:
Protective effects of exercise on heart and aorta in high-fat diet-induced obese rats

dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsElmas, Merve Acikel; Cakici, Seyit Enes; Dur, Ismail Rahmi; Kozluca, Ibrahim; Arinc, Melih; Binbuga, Berkant; Ozakpinar, Ozlem Bingol; Kolgazi, Meltem; Sener, Goksel; Ercan, Feriha
dc.date.accessioned2022-03-12T22:38:20Z
dc.date.available2022-03-12T22:38:20Z
dc.date.issued2019
dc.description.abstractWe investigated the protective effects of swimming exercise on high-fat diet-induced heart and aorta damage by evaluating oxidative stress and the endothelial nitric oxide (NO) system. Sprague Dawley rats were fed either standard chow (STD, 6% fat) or high-fat diet (HFD; 45% fat) for 18 weeks, with half of the animals trained by daily swimming sessions (EXC; 1 h per day for 5 days/week) for the last 6 weeks of the experimental period and half kept sedentary (SED). Heart and aorta tissues were prepared for routine light and electron microscopy evaluation. Endothelial NOS (eNOS) and inducible NOS (iNOS) distribution in the tissue samples were examined by immunohistochemistry. Biochemical examinations, including blood serum lipid profiles, malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and tissue NO levels were measured. Deteriorated heart and aorta morphology, increased MDA levels and iNOS-immunoreactivity (iNOS-ir), as well as decreased GSH, NO, SOD, and eNOS-ir parameters were observed in the HFD+ SED group. These morphological and biochemical parameters were ameliorated in the HFD+ EXC group. Our study revealed that obesity-induced iNOS activation and increased oxidative stress in cardiac and aorta tissues. Exercise protected the obesity-induced cardiac and aortic tissue damage by modulating oxidant/antioxidant balance via involvement of the NO system.
dc.identifier.doi10.1016/j.tice.2019.01.005
dc.identifier.issn0040-8166
dc.identifier.pubmed30947964
dc.identifier.urihttps://hdl.handle.net/11424/235596
dc.identifier.wosWOS:000462932200008
dc.language.isoeng
dc.publisherCHURCHILL LIVINGSTONE
dc.relation.ispartofTISSUE & CELL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHigh-fat diet
dc.subjectExercise
dc.subjectAorta
dc.subjectHeart
dc.subjectNitric oxide synthase
dc.subjectUltrastructure
dc.subjectMAST-CELL ACTIVATION
dc.subjectOXIDATIVE STRESS
dc.subjectREGULAR EXERCISE
dc.subjectENDOTHELIAL DYSFUNCTION
dc.subjectTNF-ALPHA
dc.subjectINJURY
dc.subjectTISSUE
dc.subjectHYPERTENSION
dc.subjectCHOLESTEROL
dc.subjectDISEASES
dc.titleProtective effects of exercise on heart and aorta in high-fat diet-induced obese rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id46c1ff3d-542c-4ffc-b901-6909fa938dff
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.endPage65
oaire.citation.startPage57
oaire.citation.titleTISSUE & CELL
oaire.citation.volume57
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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