Publication: Frequency and safety of COVID-19 vaccination in children with multisystem inflammatory syndrome: a telephonic interview-based analysis.
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Date
2022-10-01
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Abstract
Coronavirus disease 2019 (COVID-19) vaccines are currently
approved or authorized to prevent serious outcomes,
such as severe disease, hospitalization, and death. The Pfizer-
BioNTech vaccine is recommended for everyone aged five
and older in the United States (US) to prevent severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
[1, 2]. However, it is unclear whether children with a history
of multisystem, inflammatory syndrome in children (MIS-C)
may be at risk for a MIS-like response following COVID-19
vaccination or SARS-CoV-2 reinfection [2]. Therefore, physicians
remain uncertain about vaccinating children with a
history of MIS-C. This study investigates the occurrence of
severe, systemic side effects of COVID-19 vaccines and the
recurrence of the MIS-C symptoms in children with a history
of MIS-C to overcome vaccine hesitancy.
We recruited children with a history of MIS-C diagnosed
between April 2020 and December 2021 in seven hospitals
in different regions of Turkey. Our study included three
groups of children: (1) those with a history of MIS-C who met
the US Center for Disease Control (CDC) or World Health
Organization definitions for MIS-C [3, 4]; (2) those with a
history of severe/critical COVID-19 [5]; (3) and those visiting
hospitals for another reason and had no history of severe/
critical COVID-19 or MIS-C (controls). Children were called
by phone and were asked to complete a questionnaire. We
checked their vaccination status in the mobile application
developed by the Republic of Turkey Ministry of Health to
inform and guide citizens about COVID-19. Turkey authorized
the Pfizer-BioNTech (mRNA) and Sinovac (inactivated
virus) vaccines only for children aged 12 years or older.
We developed a questionnaire including questions adopted
from previous studies and new questions related to vaccine
side effects reported by the CDC [6, 7]. Children with a
MIS-C and severe/critical COVID-19 diagnosis and children
without a MIS-C or severe/critical COVID-19 history were
called by phone and were asked a standard set of questions
that included their age, gender, and COVID-19 vaccination
status. If the child had received a COVID-19 vaccination, we
asked about the date of vaccination, the brand of the vaccine
given, doses, side effects experienced (including their date
and duration), polyclinic visit, and hospitalization. Children
were asked about local and systemic reactions. Parents were
asked questions about factors affecting their vaccination decision,
including infection or reinfection anxiety in their family,
information disseminated via social media, and advice from
schools, friends, doctors, and the healthcare ministry.
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Keywords
PEDİATRİ, Klinik Tıp, Klinik Tıp (MED), PEDIATRICS, CLINICAL MEDICINE, Clinical Medicine (MED)
Citation
Aykac K., Ozturk K., Demir O. O., Gumus D. D., Aslan S., Cem E., Celebi M. Y., Karabacak M. D., Alkan G., Aksoy F. D., et al., "Frequency and safety of COVID-19 vaccination in children with multisystem inflammatory syndrome: a telephonic interview-based analysis.", World journal of pediatrics : WJP, cilt.18, ss.700-705, 2022