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Physical and mental fatigue in myasthenia gravis and its correlation with other symptoms

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dc.contributor.authorULUÇ, KAYIHAN
dc.contributor.authorKAHRAMAN KOYTAK, PINAR
dc.contributor.authorsAkkan Suzan A., Kahraman Koytak P., Uluc K., Tanridag T.
dc.date.accessioned2023-04-03T10:27:22Z
dc.date.available2023-04-03T10:27:22Z
dc.date.issued2022-08-01
dc.description.abstractIntroduction:Muscle weakness and easy fatigability are the clinical hallmarks of myasthenia gravis (MG). However, fatigue perception, which can be seen quite often in myasthenic patients, and its effect on the quality of life, irrespective of motor deficit, has not been elucidated yet. The aim is to evaluate the frequency of fatigue in myasthenic patients with nearly full muscle strength and the effect of fatigue on quality of life by assessing its correlation with other symptoms.Methods:Fifty-three patients with ocular or mild generalized MG in remission or minimal manifestations completed the questionnaires measuring the severity of MG and quality of life (MG Composite Scale and MG-Activities of Daily Living Profile). Both patient group and control group (53 healthy volunteers)completed the scales assessing fatigue [Fatigue Assessment Scale (FAS) and Fatigue Impact Scale (FIS)], depression [Beck Depression Inventory (BDI)] and sleep (Epworth Sleepiness Scale). Disease severity was assessed using MG Foundation of America (MGFA) and MGFA Post-Intervention Status classifications.Results:FAS, FIS physical and BDI scores were significantly higher in patients compared to the control group (p = 0.003, p = 0.001, and p = 0.003, respectively) and fatigue was associated with depression and daytime sleepiness. Inpatient group, depressive symptoms and daytime sleepiness were higher in females (p = 0.019 and p = 0.013). The mean values of FIS total and cognitive scores were higher in patients with generalized MG (p = 0.033 and p = 0.045). Fatigue scores correlated with motor signs.Discussion:Fatigue can be seen in MG independently from muscle weakness and is an important symptom worsening the quality of life.
dc.identifier.citationAkkan Suzan A., Kahraman Koytak P., Uluc K., Tanridag T., "Physical and mental fatigue in myasthenia gravis and its correlation with other symptoms.", Acta neurologica Belgica, cilt.122, sa.4, ss.915-923, 2022
dc.identifier.doi10.1007/s13760-022-01919-y
dc.identifier.endpage923
dc.identifier.issn0300-9009
dc.identifier.issue4
dc.identifier.startpage915
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35334084/
dc.identifier.urihttps://hdl.handle.net/11424/288102
dc.identifier.volume122
dc.language.isoeng
dc.relation.ispartofActa neurologica Belgica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectNeurology
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NÖROLOJİ
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectCLINICAL NEUROLOGY
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectFamily Practice
dc.subjectNeurology (clinical)
dc.subjectFundamentals and Skills
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectInternal Medicine
dc.subjectAssessment and Diagnosis
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectLife Sciences
dc.subjectMyasthenia gravis
dc.subjectFatigue
dc.subjectQuality of life
dc.subjectDepression
dc.subjectSleepiness
dc.subjectQUALITY-OF-LIFE
dc.subjectTURKISH VERSION
dc.subjectRELIABILITY
dc.subjectSLEEPINESS
dc.subjectINSTRUMENT
dc.subjectVALIDITY
dc.subjectIMPACT
dc.subjectSCALE
dc.subjectMyasthenia gravis
dc.subjectFatigue
dc.subjectQuality of life
dc.subjectDepression
dc.subjectSleepiness
dc.titlePhysical and mental fatigue in myasthenia gravis and its correlation with other symptoms
dc.typearticle
dspace.entity.typePublication
local.avesis.id606e48cd-939f-4751-a4f3-4171df97177f
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationdc0a3fb8-cb2f-44b7-9555-f625f8cd5110
relation.isAuthorOfPublicatione36e3211-d5a8-4593-8110-789bc04a4dd0
relation.isAuthorOfPublication.latestForDiscoverydc0a3fb8-cb2f-44b7-9555-f625f8cd5110

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