Publication:
Cannabinoids and neuroinflammation: Therapeutic implications

Loading...
Thumbnail Image

Date

2023-04-01

Journal Title

Journal ISSN

Volume Title

Publisher

Research Projects

Organizational Units

Journal Issue

Abstract

This review summarizes the pharmacological properties of tetrahydrocannabinol (THC) and cannabidiol (CBD), cannabinoid components of several species of herbal cannabis. The pharmacological effects of the phytocannabinoids have been extensively investigated and the importance of the cannabinoid receptors (CB1 and CB2) on immune cells has provided important information on the intracellular targets for these molecules. In addition to the phytocannabinoids, endogenous cannabinoids also exist in the form of anadramide and 2-srodolylglycerol (2-AG). These, together with their synthesizing and metabolizing enzymes, form the cannabinoid system. Since the discovery of the endocannabinoid system and the role that neuroinflammation plays in neurological and psychiatric illness, the potential therapeutic importance of this system has been of growing interest. In addition, the need to develop drugs which specifically target the CB1 and CB2 receptors has been stimulated by the pharmacological complexity of both THC and CBD. This review briefly summarizes the therapeutic potential of the naturally occurring and the synthetic cannabinoids which will need to be developed, if such drugs are to fulfill the therapeutic promise which the cannabinoids offer.

Description

Keywords

Sosyal ve Beşeri Bilimler, Psikoloji, Klinik Psikolojisi, Sağlık Bilimleri, Social Sciences and Humanities, Psychology, Clinical Psychology, Health Sciences, Klinik Tıp (MED), Temel Bilimler (SCI), Psikiyatri, PSİKOLOJİ, KLİNİK, Clinical Medicine (MED), Natural Sciences (SCI), PSYCHIATRY, PSYCHOLOGY, PSYCHOLOGY, CLINICAL, Klinik Psikoloji, Sosyal Bilimler ve Beşeri Bilimler, Psikiyatri ve Ruh Sağlığı, Social Sciences & Humanities, Psychiatry and Mental Health, anadamide and 2-AG, Anti-covid 19, endogenous cannabinoids, Microglia, Neuroinflammation, Phytocannabinoids, THC and CBD, therapeutic potential

Citation

Leonard B. E., ARICIOĞLU F., "Cannabinoids and neuroinflammation: Therapeutic implications", Journal of Affective Disorders Reports, cilt.12, 2023

Collections