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Gastrointestinal Manifestations in Children with Primary Immunodeficiencies: Single Center: 12 Years Experience

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dc.contributor.authorÖZEN, AHMET OĞUZHAN
dc.contributor.authorsAkkelle, Bilge S.; Tutar, Engin; Volkan, Burcu; Sengul, Ozlem K.; Ozen, Ahmet; Celikel, Cigdem A.; Ertem, Deniz
dc.date.accessioned2022-03-14T09:08:28Z
dc.date.available2022-03-14T09:08:28Z
dc.date.issued2019
dc.description.abstractBackground: It has been reported that 5-50% of patients with primary immune deficiencies (PID) may present with or develop gastrointestinal (GI) manifestations. Objective: This study was aimed at analyzing GI and related endoscopic, histopathological findings in children with PID. Methods: Children with PID who were evaluated by endoscopy between 2005 and 2016 were enrolled in this study. Demographic data, growth parameters, signs and symptoms at diagnosis were obtained. Results: Of 425 children with PID, 195 had GI manifestations. Forty-seven of 195 children required endoscopic investigation, 30 (63.8%) were male, and the mean age was 7.7 +/- 5 years. The rate of consanguinity was 61.7%, and the most common symptom was chronic diarrhea (57.4%). Seventy-two percent of the patients were malnourished. Giardia intestinalis was detected in 4, and Helicobacter pylori was confirmed in 8/45 (17.7%) patients. Non-celiac villous flatting was discovered in 15.5% of patients. Twelve patients were diagnosed as having immunodeficiency associated inflammatory bowel disease (IBD)-like colitis. Conclusions: PID may present with GI manifestations or develop during the course of the disease. Investigating immunodeficiency in patients with atypical GI symptoms can provide an appropriate therapeutic option, and an improved quality of life, particularly in populations with a high rate of consanguinity.
dc.identifier.doi10.1159/000492569
dc.identifier.eissn1421-9875
dc.identifier.issn0257-2753
dc.identifier.pubmed30153682
dc.identifier.urihttps://hdl.handle.net/11424/242617
dc.identifier.wosWOS:000451055100005
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofDIGESTIVE DISEASES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChild
dc.subjectEndoscopy
dc.subjectGut
dc.subjectHistopathology
dc.subjectPrimary immunodeficiency
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectINTERNATIONAL-UNION
dc.subjectENTEROPATHY
dc.subjectCLASSIFICATION
dc.subjectDEFICIENCY
dc.subjectDIAGNOSIS
dc.subjectUPDATE
dc.titleGastrointestinal Manifestations in Children with Primary Immunodeficiencies: Single Center: 12 Years Experience
dc.typearticle
dspace.entity.typePublication
local.avesis.id39cc8082-8451-4fc6-b1cc-34ca2a6a8927
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ3
oaire.citation.endPage52
oaire.citation.issue1
oaire.citation.startPage45
oaire.citation.titleDIGESTIVE DISEASES
oaire.citation.volume37
relation.isAuthorOfPublication3e9c297b-e636-4836-8f61-dc9c8b7c29cf
relation.isAuthorOfPublication.latestForDiscovery3e9c297b-e636-4836-8f61-dc9c8b7c29cf

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