Publication: Gentamicin and fluconazole loaded electrospun polymethylmethacrylate (PMMA) fibers as a novel platform for the treatment of corneal keratitis
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Abstract
In this study, 10 mg fluconazole (10 FCZ) and 10 mg gentamicin (10 GEN) loaded with 40% polymethylmethacrylate (40% PMMA) fibers were fabricated by electrospinning and the performance of the formulations (40% PMMA, 40% PMMA/10 FCZ, 40% PMMA/10 GEN, and 40% PMMA/10 FCZ/10 GEN) was tested. 10 mg Gentamicin-loaded 40% PMMA fiber mat showed a more significant zone of inhibition against the S. aureus compared to the zone of 40% PMMA/10 GEN/10 FCZ fiber. The biocompatibility test using a human adipose-derived mesenchymal stem cell (MSCs) as a cell model proved that the amount of loaded and released GEN has no toxic effects on the MSCs.
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Kimya, Fizikokimya, Polimer Karakterizasyonu, Temel Bilimler, Mühendislik ve Teknoloji, Chemistry, Physical Chemistry, Characterization of Polymers, Natural Sciences, Engineering and Technology, MALZEME BİLİMİ, BİYOMATERYAL, Malzeme Bilimi, Mühendislik, Bilişim ve Teknoloji (ENG), POLİMER BİLİMİ, Temel Bilimler (SCI), MATERIALS SCIENCE, BIOMATERIALS, MATERIALS SCIENCE, Engineering, Computing & Technology (ENG), POLYMER SCIENCE, CHEMISTRY, Natural Sciences (SCI), Biyomalzemeler, Malzeme Bilimi (çeşitli), Polimerler ve Plastikler, Kimya (çeşitli), Genel Malzeme Bilimi, Genel Kimya, Fizik Bilimleri, Biomaterials, Materials Science (miscellaneous), Polymers and Plastics, Chemistry (miscellaneous), General Materials Science, General Chemistry, Physical Sciences, Corneal keratitis, electrospinning, fiber, MICROBIAL KERATITIS, DRUG-DELIVERY, PERFORMANCE, NANOFIBERS, MANAGEMENT, Corneal keratitis, electrospinning, fiber
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GÜNDÜZ O., ULAĞ S., "Gentamicin and fluconazole loaded electrospun polymethylmethacrylate (PMMA) fibers as a novel platform for the treatment of corneal keratitis", INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2022