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Gentamicin and fluconazole loaded electrospun polymethylmethacrylate (PMMA) fibers as a novel platform for the treatment of corneal keratitis

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dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorULAĞ, SONGÜL
dc.contributor.authorsGÜNDÜZ O., ULAĞ S.
dc.date.accessioned2023-05-22T08:12:08Z
dc.date.accessioned2026-01-10T19:16:51Z
dc.date.available2023-05-22T08:12:08Z
dc.date.issued2022-05-01
dc.description.abstractIn this study, 10 mg fluconazole (10 FCZ) and 10 mg gentamicin (10 GEN) loaded with 40% polymethylmethacrylate (40% PMMA) fibers were fabricated by electrospinning and the performance of the formulations (40% PMMA, 40% PMMA/10 FCZ, 40% PMMA/10 GEN, and 40% PMMA/10 FCZ/10 GEN) was tested. 10 mg Gentamicin-loaded 40% PMMA fiber mat showed a more significant zone of inhibition against the S. aureus compared to the zone of 40% PMMA/10 GEN/10 FCZ fiber. The biocompatibility test using a human adipose-derived mesenchymal stem cell (MSCs) as a cell model proved that the amount of loaded and released GEN has no toxic effects on the MSCs.
dc.identifier.citationGÜNDÜZ O., ULAĞ S., "Gentamicin and fluconazole loaded electrospun polymethylmethacrylate (PMMA) fibers as a novel platform for the treatment of corneal keratitis", INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2022
dc.identifier.doi10.1080/00914037.2022.2071271
dc.identifier.issn0091-4037
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/00914037.2022.2071271?scroll=top&needAccess=true&role=tab&aria-labelledby=full-article
dc.identifier.urihttps://hdl.handle.net/11424/289487
dc.language.isoeng
dc.relation.ispartofINTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectChemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMALZEME BİLİMİ, BİYOMATERYAL
dc.subjectMalzeme Bilimi
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectPOLİMER BİLİMİ
dc.subjectTemel Bilimler (SCI)
dc.subjectMATERIALS SCIENCE, BIOMATERIALS
dc.subjectMATERIALS SCIENCE
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectBiyomalzemeler
dc.subjectMalzeme Bilimi (çeşitli)
dc.subjectPolimerler ve Plastikler
dc.subjectKimya (çeşitli)
dc.subjectGenel Malzeme Bilimi
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectBiomaterials
dc.subjectMaterials Science (miscellaneous)
dc.subjectPolymers and Plastics
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Materials Science
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectCorneal keratitis
dc.subjectelectrospinning
dc.subjectfiber
dc.subjectMICROBIAL KERATITIS
dc.subjectDRUG-DELIVERY
dc.subjectPERFORMANCE
dc.subjectNANOFIBERS
dc.subjectMANAGEMENT
dc.subjectCorneal keratitis
dc.subjectelectrospinning
dc.subjectfiber
dc.titleGentamicin and fluconazole loaded electrospun polymethylmethacrylate (PMMA) fibers as a novel platform for the treatment of corneal keratitis
dc.typearticle
dspace.entity.typePublication

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