Publication:
Moderation analysis exploring associations between age and mucocutaneous activity in Behcet's syndrome: A multicenter study from Turkey

dc.contributor.authorAKSOY, AYSUN
dc.contributor.authorsMumcu, Gonca; Yay, Meral; Karacayli, Umit; Aksoy, Aysun; Tas, Mehmet Nedim; Armagan, Berkan; Sari, Alper; Bozca, Burcin Cansu; Tekgoz, Emre; Temiz Karadag, Duygu; Badak, Suade ozlem; Tecer, Duygu; Yildirim, Alper; Bes, Cemal; Sahin, Ali; Erken, Eren; Cefle, Ayse; Cinar, Muhammet; Yilmaz, Sedat; Alpsoy, Erkan; Boyvat, Ayse; Senel, Soner; Bilge, Sule Yasar; Kasifoglu, Timucin; Karadag, Omer; Aksu, Kenan; Keser, Gokhan; Alibaz-oner, Fatma; Inanc, Nevsun; Ergun, Tulin; Direskeneli, Haner
dc.date.accessioned2022-03-12T22:54:58Z
dc.date.available2022-03-12T22:54:58Z
dc.date.issued2020
dc.description.abstractThe aim of the present study was to examine the effects of age on mucocutaneous activity by using moderation analysis in Behcet's syndrome (BS). In this cross-sectional study, 887 BS patients (female : male, 481:406; mean age, 38.4 +/- 10.9 years) followed in 13 tertiary centers in Turkey were included. Mucocutaneous activity was evaluated by using the Mucocutaneous Index (MI) according to sex and disease course. Moderation analysis was performed to test the effect of age on mucocutaneous activity. A moderator variable is a third variable and affects the relationship between independent and outcome variables. Age was chosen as a potential moderator variable (interaction effect), MI score as the outcome variable and sex as an independent variable in the analysis. The moderation analysis tested the effects of age in three steps: whole BS patient group, patients without systemic involvement and those with systemic involvement. The moderation model was only significant in BS patients with systemic involvement (P = 0.0351), and a significant relationship was observed between female sex and MI score (P = 0.0156). In addition, the interaction plot showed that female patients had increased MI scores compared with male patients, especially in the 28-year-old age group (P = 0.0067). Moreover, major organ involvement was newly diagnosed in the majority of these young female BS patients. Our results suggest that the relationship between sex and mucocutaneous activity was moderated by age in the systemic involvement group. Also, increased mucocutaneous activity may be associated with new major organ involvement in young female BS patients with systemic involvement.
dc.identifier.doi10.1111/1346-8138.15553
dc.identifier.eissn1346-8138
dc.identifier.issn0385-2407
dc.identifier.pubmed32981075
dc.identifier.urihttps://hdl.handle.net/11424/236597
dc.identifier.wosWOS:000572763700001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF DERMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBehcet's syndrome
dc.subjectmoderation analysis
dc.subjectmucocutaneous activity
dc.subjectMucocutaneous Index
dc.subjectsex
dc.subjectORAL ULCER ACTIVITY
dc.subjectQUALITY-OF-LIFE
dc.subjectDISEASE-ACTIVITY
dc.subjectOUTCOME MEASURES
dc.subjectCOMPOSITE INDEX
dc.subjectMANIFESTATIONS
dc.subjectINVOLVEMENT
dc.subjectSEVERITY
dc.subjectMEDIATOR
dc.subjectHEALTH
dc.titleModeration analysis exploring associations between age and mucocutaneous activity in Behcet's syndrome: A multicenter study from Turkey
dc.typearticle
dspace.entity.typePublication
local.avesis.id0bc614e7-905a-4612-bd74-a48ddf335f3c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ2
oaire.citation.endPage1410
oaire.citation.issue12
oaire.citation.startPage1403
oaire.citation.titleJOURNAL OF DERMATOLOGY
oaire.citation.volume47
relation.isAuthorOfPublication8c3b9d86-3f58-4d22-a92a-a6bc58ce5e72
relation.isAuthorOfPublication.latestForDiscovery8c3b9d86-3f58-4d22-a92a-a6bc58ce5e72

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