Publication: A new series of 1,3,4-oxadiazole derivatives: Synthesis and evaluation of antimicrobial activity
No Thumbnail Available
Date
2021-11-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aim: Infectious diseases have become more and more life-threatening illnesses. Despite a large
number of antimicrobial agents, deaths due to infectious diseases are increasing day by day.
Antimicrobial drugs have remained insufficiently against some infectious diseases caused
outbreaks such as Zika, Ebola, SARS and MERS coronaviruses during the last decades.
Therefore, new antimicrobial agents are urgently needed. 1,3,4-Oxadiazole ring is an important
pharmacophoric group which is exhibited a broad spectrum of pharmacological activity profile
including their antibacterial, antifungal, antiviral, antimalarial, antitubercular properties (1). In
this study, we aimed the synthesis of new 1,3,4-oxadiazole rings and evaluation of their
antimicrobial activity.
Methods: New 2,5-disubstituted-1,3,4-oxadiazoles were synthesized at three steps. All
compounds were characterized with spectral methods such as IR, 1H-NMR, 13C-NMR and
elemental analysis. The antimicrobial activity of 1,3,4-oxadiazoles was screened on four
bacteria and three fungi according to our previous method (2). Enterococcus faecalis,
Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus were used for antibacterial
activity; Candida albicans, Candida parapsilosis and Candida glabrata were used for
anticandidal activity.
Results: Minimum inhibitory concentration (MIC) was determined for test compounds and for
the reference standards chloramphenicol, ketoconazole. The compound carrying methoxy
substituent on the para position of the aromatic ring exhibited the same antibacterial activity as
chloramphenicol against E. faecalis with a MIC50 value of 62.50 µM/mL.
Conclusions: According to the results, we demonstrated that some compounds exhibit
antimicrobial activities against tested microorganisms. Therefore, the oxadiazole nucleus is
promising for new drug candidates.
Description
Keywords
Antibacterial, antifungal, 1, 3, 4-oxadiazole
Citation
TOK F., ÖZARDA M. G., \"A new series of 1,3,4-oxadiazole derivatives: Synthesis and evaluation of antimicrobial activity\", Union Of Thrace Universities 4th International Health Sciences Congress, Kırklareli, Türkiye, 11 - 12 Kasım 2021, ss.185