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Protective Effects of Origanum onites Essential Oil in the Methotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity

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dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorsAykac, Asli; Becer, Eda; Ozbeyli, Dilek; Sener, Goksel; Baser, Kemal Husnu Can
dc.date.accessioned2022-03-14T10:11:48Z
dc.date.available2022-03-14T10:11:48Z
dc.date.issued2020-07-27
dc.description.abstractMethotrexate (MTX) is an effective cytotoxic agent which is used to treat malignancies and inflammatory diseases. Origanum onites (O. onites) is found throughout the Eastern Mediterranean region and has been used in traditional medicine. The essential oils (EOs) of O. onites rich in highly bioactive phytochemicals such as carvacrol (CVR) and has antiviral, antioxidant, anticancer and proapoptotic properties. The aim of this study was to investigate the protective effects of CVR and O. onites-EO treatment in MTX-induced hepatorenal toxic rats' liver and kidney tissues. The bcl-2/bax ratio, glutathione (GSH) level, malondialdehyde (MDA) level, and myeloperoxidase (MPO) activity of liver and kidney tissues were evaluated in the MTX-induced rat model. Results showed that the administration of CVR or O. onites-EO significantly increased bcl-2/bax expression and GSH levels as well as reduced MDA level and MPO activity in the kidney and liver tissues of MTX-induced rat model. In conclusion, our results suggest that O. onites-EO and CVR have protective effect in MTX-induced hepatorenal toxic rats' liver and kidney tissues by decreasing oxidative stress and apoptosis.
dc.identifier.doi10.25135/rnp.186.20.04.1631
dc.identifier.issn1307-6167
dc.identifier.urihttps://hdl.handle.net/11424/244190
dc.identifier.wosWOS:000555468800002
dc.language.isoeng
dc.publisherACG PUBLICATIONS
dc.relation.ispartofRECORDS OF NATURAL PRODUCTS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMethotrexate
dc.subjectOriganum onites
dc.subjectessential oil
dc.subjecthepatorenal toxicity
dc.subjectL. ESSENTIAL OIL
dc.subjectOXIDATIVE STRESS
dc.subjectCARVACROL
dc.subjectANTIOXIDANT
dc.subjectINJURY
dc.subjectHEPATOTOXICITY
dc.subjectPROTEINS
dc.subjectLIVER
dc.subjectACID
dc.titleProtective Effects of Origanum onites Essential Oil in the Methotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity
dc.typearticle
dspace.entity.typePublication
local.avesis.id3ca1f285-5238-4f63-8c72-0c1e1854e2ec
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages10
local.journal.quartileQ3
oaire.citation.endPage404
oaire.citation.issue6
oaire.citation.startPage395
oaire.citation.titleRECORDS OF NATURAL PRODUCTS
oaire.citation.volume14
relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublication.latestForDiscovery4681bb67-e40b-4cf0-8154-5472237f2325

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