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3D printing of PVA/hexagonal boron nitride/bacterial cellulose composite scaffolds for bone tissue engineering

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dc.contributor.authorŞENGÖR, MUSTAFA
dc.contributor.authorsAki, Deniz; Ulag, Songul; Unal, Semra; Sengor, Mustafa; Ekren, Nazmi; Lin, Chi-Chang; Yilmazer, Hakan; Ustundag, Cem Bulent; Kalaskar, Deepak M.; Gunduz, Oguzhan
dc.date.accessioned2022-03-14T09:25:32Z
dc.date.available2022-03-14T09:25:32Z
dc.date.issued2020-11
dc.description.abstractIn this study, a novel Polyvinyl Alcohol (PVA)/Hexagonal Boron Nitride (hBN)/Bacterial Cellulose (BC) composite, bone tissue scaffolds were fabricated using 3D printing technology. The printed scaffolds were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), tensile testing, swelling behaviour, differential scanning calorimetry (DSC), and in vitro cell culture assay. Results demonstrated that bacterial cellulose addition affected the characteristic properties of the blends. Morphological studies revealed the homogenous dispersion of the bacterial cellulose within the 12 wt%PVA/0.25 wt%hBN matrix. Tensile strength of the scaffolds was decreased with the incorporation of BC and 12 wt%PVA/0.25 wt%hBN/0.5 wt%BC had the highest elongation at break value (93%). A significant increase in human osteoblast cell viability on 3D scaffolds was observed for 12 wt%PVA/0.25 wt%hBN/0.5 wt%BC. Cell morphology on composite scaffolds showed that bacterial cellulose doped scaffolds appeared to adhere to the cells. The present work deduced that bacterial cellulose doped 3D printed scaffolds with well-defined porous structures have considerable potential as a suitable tissue scaffold for bone tissue engineering (BTE). (c) 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
dc.identifier.doi10.1016/j.matdes.2020.109094
dc.identifier.eissn1873-4197
dc.identifier.issn0264-1275
dc.identifier.urihttps://hdl.handle.net/11424/243106
dc.identifier.wosWOS:000588269300003
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofMATERIALS & DESIGN
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBacterial cellulose
dc.subjectBone tissue engineering
dc.subjectHexagonal boron nitride
dc.subjectOsteoblast cell line
dc.subjectPolyvinyl alcohol
dc.subject3D bioprinting
dc.subjectBACTERIAL CELLULOSE
dc.subjectPOLY(VINYL ALCOHOL)
dc.subjectTECHNOLOGY
dc.subjectREPAIR
dc.title3D printing of PVA/hexagonal boron nitride/bacterial cellulose composite scaffolds for bone tissue engineering
dc.typearticle
dspace.entity.typePublication
local.avesis.idfe3d9792-ec71-4865-a901-048c20d40280
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber109094
local.journal.numberofpages9
local.journal.quartileQ1
oaire.citation.titleMATERIALS & DESIGN
oaire.citation.volume196
relation.isAuthorOfPublication290efe89-ff1c-49a8-aae2-5a7b727f68a1
relation.isAuthorOfPublication.latestForDiscovery290efe89-ff1c-49a8-aae2-5a7b727f68a1

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