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Low Titer Tissue Transglutaminase Antibodies: A Link to Helicobacter pylori Infection?

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dc.contributor.authorÇELİKEL, ÇİĞDEM
dc.contributor.authorsAkkelle, Bilge S.; Sengul, Ozlem K.; Tutar, Engin; Volkan, Burcu; Celikel, Cigdem; Ertem, Deniz
dc.date.accessioned2022-03-12T22:55:02Z
dc.date.available2022-03-12T22:55:02Z
dc.description.abstractIntroduction: Low serum titer of anti-tissue transglutaminase (tTG) has been described in various conditions without any evidence of celiac disease (CD). Infectious agents have been suggested to trigger autoimmunity and promote the production of anti-tTG. The aim of this study was to investigate if there is a link between a positive celiac serology and concomitant Helicobacter pylori infection in children. Methods: The data of 178 pediatric patients who underwent upper gastrointestinal endoscopy due to positive celiac serology were compiled. The patients whose histopathologic findings were not consistent with CD were followed on gluten-containing diet. The changes in the serum level of anti-tTG IgA on the follow-up were compared between H. pylori-infected and noninfected patients after the eradication of H. pylori. Results: Of 155 patients who met the inclusion criteria, 119 (group 1) were diagnosed as CD, and duodenal histopathology of the remaining 36 children (group 2) was not compatible with CD. In group 2, 11 out of 36 (30.5%) patients were infected with H. pylori. After the eradication of H. pylori, anti-tTG IgA level either decreased or dropped below cutoff value in 9/11 (81%) patients while it was 20% in those who were not infected with H. pylori in the 6th month of the follow-up (p = 0.001). Conclusion: Our results suggest that H. pylori infection may be the cause of false or transient positive celiac serology. Thus, a positive celiac serology should be carefully interpreted in the presence of H. pylori infection before confirming the diagnosis of this life-long disease.
dc.identifier.doi10.1159/000516479
dc.identifier.eissn1421-9875
dc.identifier.issn0257-2753
dc.identifier.pubmed33895735
dc.identifier.urihttps://hdl.handle.net/11424/236625
dc.identifier.wosWOS:000700012900001
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofDIGESTIVE DISEASES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCeliac serology
dc.subjectAutoantibody
dc.subjectHelicobacter pylori
dc.subjectChildren
dc.subjectDUODENAL INTRAEPITHELIAL LYMPHOCYTOSIS
dc.subjectCELIAC-DISEASE
dc.subjectCHILDREN
dc.subjectAUTOANTIBODIES
dc.subjectPREVALENCE
dc.subjectGUIDELINES
dc.subjectGLIADIN
dc.titleLow Titer Tissue Transglutaminase Antibodies: A Link to Helicobacter pylori Infection?
dc.typearticle
dspace.entity.typePublication
local.avesis.idad020a4e-872e-43fc-8f99-40d21f991deb
local.import.packageSS17
local.indexed.atWOS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.titleDIGESTIVE DISEASES
relation.isAuthorOfPublicationbc2327ed-471c-42da-86dd-cef77979cda2
relation.isAuthorOfPublication.latestForDiscoverybc2327ed-471c-42da-86dd-cef77979cda2

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