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Obestatin alleviates subarachnoid haemorrhage-induced oxidative injury in rats via its anti-apoptotic and antioxidant effects

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dc.contributor.authorŞENER, AZİZE
dc.contributor.authorsErsahin, Mehmet; Ozsavci, Derya; Sener, Azize; Ozakpinar, Ozlem Bingol; Toklu, Hale Zerrin; Akakin, Dilek; Sener, Goksel; Yegen, Berrak C.
dc.date.accessioned2022-03-12T18:09:45Z
dc.date.available2022-03-12T18:09:45Z
dc.date.issued2013
dc.description.abstractObjective: The aim was to investigate the putative anti-inflammatory and anti-apoptotic effect of obestatin in a rat model of subarachnoidal haemorrhage (SAH). Methods: To induce SAH, rats were injected with 0.3 mL blood into their cisterna magna. At 48 hours rats were decapitated after neurological examination. Blood-brain barrier (BBB) permeability, brain water content, oxidative stress markers and histological analysis were done in brain tissue. Results: The results showed that neurological examination scores were increased in the SAH group and, moreover, BBB permeability was impaired and oedema formed. SAH resulted in increased levels of plasma tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6 levels and caspase-3 activity. Lipid peroxidation and protein oxidation levels and myeloperoxidase activity were all increased in the brain tissue, with concomitant decreases in antioxidant enzymes. On the other hand, SAH-induced neurological impairment and oxidative brain injury were ameliorated in the obestatin-treated group. Conclusion: The present study provides the first evidence that peripheral administration of obestatin exerts potent anti-inflammatory and neuroprotective effects in SAH-induced oxidative damage by maintaining a balance in oxidant-antioxidant status through the augmentation of endogenous antioxidants and the inhibition of pro-inflammatory mediators.
dc.identifier.doi10.3109/02699052.2013.804199
dc.identifier.eissn1362-301X
dc.identifier.issn0269-9052
dc.identifier.pubmed23895491
dc.identifier.urihttps://hdl.handle.net/11424/231316
dc.identifier.wosWOS:000323365200011
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofBRAIN INJURY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectobestatin
dc.subjectoxidative
dc.subjectstress
dc.subjectsubarachnoid haemorrhage
dc.subjectBLOOD-BRAIN-BARRIER
dc.subjectCOGNITIVE DYSFUNCTION
dc.subjectMESSENGER-RNA
dc.subjectGHRELIN
dc.subjectEXPRESSION
dc.subjectVASOSPASM
dc.subjectDAMAGE
dc.subjectSTRESS
dc.subjectOXYHEMOGLOBIN
dc.subjectPROTECTS
dc.titleObestatin alleviates subarachnoid haemorrhage-induced oxidative injury in rats via its anti-apoptotic and antioxidant effects
dc.typearticle
dspace.entity.typePublication
local.avesis.idf4536aae-0d62-4348-8bb0-0512c3e1bff7
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage1189
oaire.citation.issue10
oaire.citation.startPage1181
oaire.citation.titleBRAIN INJURY
oaire.citation.volume27
relation.isAuthorOfPublicationfd65174e-4126-41c3-913d-e8bcdce20632
relation.isAuthorOfPublication.latestForDiscoveryfd65174e-4126-41c3-913d-e8bcdce20632

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