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Liraglutide for weight management in children and adolescents with prader-willi syndrome and obesity

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dc.contributor.authorDEMİRCİOĞLU, SERAP
dc.contributor.authorsDiene G., Angulo M., Hale P. M. , Jepsen C. H. , Hofman P. L. , Hokken-Koelega A., Ramesh C., DEMİRCİOĞLU S., Tauber M.
dc.date.accessioned2022-10-26T07:39:47Z
dc.date.available2022-10-26T07:39:47Z
dc.date.issued2022-10-01
dc.description.abstractContext Prader-Willi syndrome (PWS) is characterized by lack of appetite control and hyperphagia, leading to obesity. Pharmacological options for weight management are needed. Objective To determine whether liraglutide treatment for weight management is superior to placebo/no treatment in pediatric individuals with PWS. Methods This was a multicenter, 52-week, placebo-controlled trial with a 16-week double-blinded period. Adolescents (n = 31, aged 12-17 years; Tanner stage 2-5) and children (n = 24, aged 6-11 years; Tanner stage <2) with PWS and obesity were included. Patients were randomized 2:1 to liraglutide 3.0 mg (or maximum-tolerated dose) or placebo for 16 weeks, after which placebo was stopped. Liraglutide was continued for 52 weeks. All patients followed a structured diet and exercise program throughout the trial. The coprimary endpoints were change in body mass index (BMI) standard deviation score (SDS) from baseline to 16 and 52 weeks. Secondary endpoints included other weight-related parameters, hyperphagia, and safety. Results Change in BMI SDS from baseline to weeks 16 and 52 was not significantly different between treatments in adolescents (estimated treatment difference: -0.07 at week 16 and -0.14 at week 52) and children (-0.06 and -0.07, respectively). Changes in other weight-related parameters between treatments were not significant. At week 52, hyperphagia total and drive scores were lower in adolescents treated with liraglutide vs no treatment. The most common adverse events with liraglutide were gastrointestinal disorders. Conclusion Although the coprimary endpoints were not met, changes in hyperphagia total and drive scores in adolescents warrant further studies on liraglutide in this population.
dc.identifier.citationDiene G., Angulo M., Hale P. M. , Jepsen C. H. , Hofman P. L. , Hokken-Koelega A., Ramesh C., DEMİRCİOĞLU S., Tauber M., "Liraglutide for Weight Management in Children and Adolescents With Prader-Willi Syndrome and Obesity", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022
dc.identifier.doi10.1210/clinem/dgac549
dc.identifier.issn0021-972X
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/3559086e-6885-4258-9f8c-9f0c350556d4/file
dc.identifier.urihttps://hdl.handle.net/11424/282630
dc.language.isoeng
dc.relation.ispartofJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectHealth Sciences
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectEndokrin ve Otonom Sistemler
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectEndokrinoloji
dc.subjectYaşam Bilimleri
dc.subjectEndocrine and Autonomic Systems
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectEndocrinology
dc.subjectLife Sciences
dc.subjectPrader-Willi Syndrome
dc.subjectobesity
dc.subjectchildren
dc.subjectadolescents
dc.subjectpediatric population
dc.subjectBMI SDS
dc.subjectAPPETITE
dc.subjectADULTS
dc.titleLiraglutide for weight management in children and adolescents with prader-willi syndrome and obesity
dc.typearticle
dspace.entity.typePublication
local.avesis.id3559086e-6885-4258-9f8c-9f0c350556d4
local.indexed.atWOS
local.indexed.atPUBMED
relation.isAuthorOfPublication1c59e516-384a-4161-af91-3c3088f49d21
relation.isAuthorOfPublication.latestForDiscovery1c59e516-384a-4161-af91-3c3088f49d21

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