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Protective effect of alpha-lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

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dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorsOzbeyli, Dilek; Berberoglu, Ayse Cansu; Ozen, Anil; Erkan, Oktay; Basar, Yunus; Sen, Tunahan; Akakin, Dilek; Yuksel, Meral; Cakir, Ozgur Kasimay
dc.date.accessioned2022-03-12T20:31:16Z
dc.date.available2022-03-12T20:31:16Z
dc.date.issued2017
dc.description.abstractThe role of second hand smoke (SHS) exposure on ulcerative colitis is not known. Our aim was to examine the effects of -lipoic acid (ALA), chronic aerobic (AE) or resistance exercise (RE) on SHS exposed rats with colitis. Sprague-Dawley male rats (150-200g, n=54) were selected for colitis induction. Among the colitis groups, one group was exposed to SHS (6d/wk, 4cigarettes/d) and the other was not. The SHS group was divided into subgroups as follows: sedentary; AE (swimming; 3d/wk); and RE (climbing with weight; 3d/wk). After 5weeks, colitis was induced by intrarectal acetic acid. All groups had subgroups that were given subcutaneously ALA (50mg/kg per day) or vehicle for 3days. Following decapitation, colon tissues were sampled to examine malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, luminol and lucigenin chemiluminenscence, macroscopic scoring and histologic examination. ANOVA and Student's t-test were used for statistical analysis. The increased macroscopic and microscopic scores, MPO, MDA, luminol and lucigenin measurements in colitis and SHS-colitis groups were decreased via ALA (P<.05-.001). AE declined macroscopic and microscopic scores, MDA, lucigenin compared to colitis and SHS-colitis groups (P<.01-.001). RE reduced microscopic score, MPO, MDA, luminol, lucigenin (P<.05-.001) that were increased with colitis. Decreased GSH levels (P<.01) in the SHS-colitis group approached to control levels when given ALA. According to our results SHS and colitis induction increased inflammatory damage. SHS did not worsen it more than colitis. Our results suggest that ALA, AE or RE might be protective for SHS exposed ulcerative colitis conditions.
dc.identifier.doi10.1111/1440-1681.12682
dc.identifier.eissn1440-1681
dc.identifier.issn0305-1870
dc.identifier.pubmed27718277
dc.identifier.urihttps://hdl.handle.net/11424/234269
dc.identifier.wosWOS:000392499000007
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectacetic acid-induced colitis
dc.subjectoxidative damage
dc.subjectpassive smoking
dc.subjectphysical activity
dc.subjectINDUCED ULCERATIVE-COLITIS
dc.subjectTRINITROBENZENE SULFONIC-ACID
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectOXIDATIVE STRESS
dc.subjectACETIC-ACID
dc.subjectISCHEMIA-REPERFUSION
dc.subjectNICOTINE
dc.subjectDAMAGE
dc.subjectMECHANISMS
dc.subjectRADICALS
dc.titleProtective effect of alpha-lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id77a73196-9f3f-4d9d-855f-9618e6eef814
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ3
oaire.citation.endPage70
oaire.citation.issue1
oaire.citation.startPage62
oaire.citation.titleCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
oaire.citation.volume44
relation.isAuthorOfPublicationc97c0ebf-ffce-4b27-a933-941a53767b0d
relation.isAuthorOfPublication.latestForDiscoveryc97c0ebf-ffce-4b27-a933-941a53767b0d

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