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The antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction

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dc.contributor.authorYARAT, AYŞEN
dc.contributor.authorsGocmen, Gokhan; Gonul, Onur; Oktay, Nihal Sehkar; Yarat, Aysen; Goker, Kamil
dc.date.accessioned2022-03-13T12:48:14Z
dc.date.available2022-03-13T12:48:14Z
dc.date.issued2015
dc.description.abstractPurpose: Hyaluronic acid (HA) has a number of clinical applications in current practice. Therefore, correlation of HA with free radicals and inflammatory cells is clinically important. The purpose of this study is to measure the efficacy of high molecular weight HA on the oxidative stress of oral wounds (glutathione (GSH) and lipid peroxidation (LPO) levels), the inflammatory reaction (leucocytes, collagen and angiogenesis content), pain (visual analogue scale (VAS) records) and trismus (maximum interincisal opening (MIO) records) after third molar (M3) extraction. Patients and methods: 40 patients were included in this study. 0.2 ml 0.8% HA was applied immediately after surgery within the HA group (n = 20). Nothing was applied to the control group (n = 20). The primary outcome variables were the changes in the inflammatory reaction (leucocyte, angiogenesis and collagen content), oxidative stress (GSH, LPO) and clinical parameters (VAS, MIO). Results were compared immediately after extraction (TO) and 1 week after surgery (T1). Bivariate analyses were used to assess the differences between the HA and control groups for each study variable. Results: There was a statistically significant difference of leucocyte infiltration and angiogenesis between the groups at T1. The HA group showed less leucocyte infiltration and more angiogenesis than the control group. There was no statistically significant difference in oxidative stress, VAS or MIO levels between the groups. Conclusion: Our results confirm the hypothesis that HA has an anti-inflammatory effect following M3 extraction. However, the oxidative stress levels and clinical outcomes were similar after one week. Further studies examining these parameters at different times are necessary. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.jcms.2015.04.022
dc.identifier.eissn1878-4119
dc.identifier.issn1010-5182
dc.identifier.pubmed26027861
dc.identifier.urihttps://hdl.handle.net/11424/238181
dc.identifier.wosWOS:000361078700008
dc.language.isoeng
dc.publisherCHURCHILL LIVINGSTONE
dc.relation.ispartofJOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHyaluronic acid
dc.subjectThird molar extraction
dc.subjectWound healing
dc.subjectDAMAGE
dc.subjectSURGERY
dc.subjectREPAIR
dc.subjectTISSUE
dc.titleThe antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction
dc.typearticle
dspace.entity.typePublication
local.avesis.id54975f73-1fd0-4b4d-8147-5f4bbf0e3a33
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage1037
oaire.citation.issue7
oaire.citation.startPage1033
oaire.citation.titleJOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
oaire.citation.volume43
relation.isAuthorOfPublication46115086-6b46-4ef8-aaf1-ab8eda3e917e
relation.isAuthorOfPublication.latestForDiscovery46115086-6b46-4ef8-aaf1-ab8eda3e917e

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