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Lycopene inhibits caspase-3 activity and reduces oxidative organ damage in a rat model of thermal injury

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dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorsCevik, Ozge; Oba, Rabia; Macit, Caglar; Cetinel, Sule; Kaya, Ozlem Tugce Cilingir; Sener, Emre; Sener, Goksel
dc.date.accessioned2022-03-12T18:06:08Z
dc.date.available2022-03-12T18:06:08Z
dc.date.issued2012
dc.description.abstractOxidative stress has been implicated in various pathological processes including burn induced multiple organ damage. This study investigated the effects of lycopene treatment against oxidative injury in rats with thermal trauma. Under ether anesthesia, shaved dorsum of the rats was exposed to 90 degrees C bath for 10 s to induce burn and treated either vehicle (olive oil) or lycopene (50 mg/kg orally). Rats were decapitated 48 h after injury and the tissue samples from lung and kidney were taken for histological analysis and the determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO), superoxide dismutase (SOD), catalase (CAT) and caspase-3 activities. Proinflammatory cytokines, TNF-alpha and IL-1 beta, were assayed in blood samples. Severe skin scald injury caused a significant decrease in GSH levels, SOD and CAT activities, and significant increases in MDA levels, MPO and caspase-3 activities of tissues. Similarly, plasma TNF-alpha and IL-1 beta. were elevated in the burn group as compared to the control group. Lycopene treatment reversed all these biochemical indices. According to the findings of the present study, lycopene possesses antiinflammatory, antiapoptotic and antioxidant effects that prevents burn-induced oxidative damage in remote organs. (C) 2012 Elsevier Ltd and ISBI. All rights reserved.
dc.identifier.doi10.1016/j.burns.2012.01.006
dc.identifier.eissn1879-1409
dc.identifier.issn0305-4179
dc.identifier.pubmed22356815
dc.identifier.urihttps://hdl.handle.net/11424/230844
dc.identifier.wosWOS:000307692400012
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofBURNS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBurn
dc.subjectOxidative stress
dc.subjectLycopene
dc.subjectCaspase-3
dc.subjectCytokine
dc.subjectAntioxidant
dc.subjectLIPID-PEROXIDATION
dc.subjectRENAL INJURY
dc.subjectDNA-DAMAGE
dc.subjectBURN
dc.subjectSKIN
dc.subjectPROTECTS
dc.subjectSTRESS
dc.subjectINFLAMMATION
dc.subjectMEDIATORS
dc.subjectRADIATION
dc.titleLycopene inhibits caspase-3 activity and reduces oxidative organ damage in a rat model of thermal injury
dc.typearticle
dspace.entity.typePublication
local.avesis.id0fded18b-b314-4162-9e35-9fcfab51d592
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
oaire.citation.endPage871
oaire.citation.issue6
oaire.citation.startPage861
oaire.citation.titleBURNS
oaire.citation.volume38
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublication.latestForDiscovery2fd85a89-446e-49e1-98c9-d20b11a1a2b5

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