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Determinants of Elevated NT-proBNP Levels in Patients With Hypertrophic Cardiomyopathy: An Echocardiographic Study

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dc.contributor.authorMUTLU, BÜLENT
dc.contributor.authorsKahveci, Gokhan; Bayrak, Fatih; Mutlu, Bulent; Basaran, Yelda
dc.date.accessioned2022-03-12T17:46:49Z
dc.date.available2022-03-12T17:46:49Z
dc.date.issued2009
dc.description.abstractBackground: The purpose of this study was to explore the relationship between plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and extensive echocardiographic variables in patients with hypertrophic cardiomyopathy (HCM). Methods: We evaluated plasma NT-proBNP levels in 88 patients with HCM and examined the plasma NT-proBNP levels' relationships with echocardiographic indexes. Echocardiographic variables were analysed using univariate and multivariate logistic regression to identify predictors of NT-proBNP elevation. Results: Several echocardiographic variables predicted NT-proBNP elevation, including left atrial dimension index (LADI), left ventricular maximal wall thickness (MWT), left ventricular posterior wall thickness, severe mitral regurgitation, mitral septal and lateral tissue Doppler velocities, and mitral septal E/Ea ratio. Left ventricular ejection fraction, left ventricular dimensions, mitral early flow propagation velocity, isovolumic relaxation time, and left ventricular outflow tract obstruction were not significant predictors of NT-proBNP in this group of patients. With multivariate analysis LADI (HR 5.0; 95% CI 1.5-17.1, p = 0.01) and MWT (HR 4.0; 95% CI 1.2-13.2, p = 0.022) emerged as independent determinants of NT-proBNP elevation. Conclusions: In HCM plasma NT-proBNP is prominently increased. LADI and MWT are independent predictors of elevated levels. These data indicate that NT-proBNP elevations are mainly determined by diastolic load in HCM. (Heart, Lung and Circulation 2009;18:266-270) (c) 2008 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.hlc.2008.11.001
dc.identifier.eissn1444-2892
dc.identifier.issn1443-9506
dc.identifier.pubmed19157978
dc.identifier.urihttps://hdl.handle.net/11424/229564
dc.identifier.wosWOS:000269237800004
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofHEART LUNG AND CIRCULATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHypertrophic cardiomyopathy
dc.subjectNT-proBNP
dc.subjectLeft atrium
dc.subjectVENTRICULAR FILLING PRESSURES
dc.subjectNATRIURETIC PEPTIDE LEVELS
dc.titleDeterminants of Elevated NT-proBNP Levels in Patients With Hypertrophic Cardiomyopathy: An Echocardiographic Study
dc.typearticle
dspace.entity.typePublication
local.avesis.idb9b10274-0449-4d3e-8ff8-b0d65ecdca2c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
oaire.citation.endPage270
oaire.citation.issue4
oaire.citation.startPage266
oaire.citation.titleHEART LUNG AND CIRCULATION
oaire.citation.volume18
relation.isAuthorOfPublicationeed1d57d-2fc5-4da3-ab50-89ce22ccf43a
relation.isAuthorOfPublication.latestForDiscoveryeed1d57d-2fc5-4da3-ab50-89ce22ccf43a

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