Publication:
A developmental study of glutamatergic neuron populations in the ventrobasal and the lateral geniculate nucleus of the thalamus: Comparing Genetic Absence Rats from Strasbourg (GAERS) and normal control wistar rats

Simple item page
dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsKirazhi, Ozlem; Caydar, Safiye; Yildizel, Sercan; Onat, Filiz; Kaptanoglu, Erkan
dc.date.accessioned2022-03-12T20:32:39Z
dc.date.available2022-03-12T20:32:39Z
dc.date.issued2017
dc.description.abstractAn imbalance of GABAergic inhibition and glutamatergic excitation is suspected to be the cause of absence epileptic seizures. Absence seizures are known to be generated in thalamocortical circuitry. In the present study we used light microscopy immunohistochemistry to quantify the density of glutamate+ve neurons at two developmental stages (P10 and P60) in two thalamic nuclei, the ventrobasal (VB) and lateral geniculate nucleus (LGN) in Wistar rats and compared the results with similar data obtained from genetic absence epilepsy rats from Strasbourg (GAERS). Rats were perfused transcardially with glutaraldehyde and paraformaldehyde fixative, then samples from VB and LGN were removed from each animal and sectioned. The glutamatergic neurons were labelled using light-microscopic glutamate immunohistochemistry. The disector method was used to quantify the glutamate+ve neurons in VB and LGN of GAERS and Wistar rats. The data were statistically analyzed. The distribution of the glutamate+ve neurons in the VB thalamic nucleus showed a significant reduction in the neuronal profiles per unit thalamic area from P10 to P60 in both Wistar and GAERS. The decrease was greater in the GAERS compared to the Wistar animals. However, in the LGN no reduction was observed either in the Wistar or in the GAERS. Comparing the density of glutamate+ve neurons in the VB thalamic nucleus of P10 of Wistar animals with of P10 GAERS showed statistically significant greater densities of these neurons in GAERS than in the Wistar rats. However no significant difference was present at P60 between the Wistar and GAERS animals. The disproportional decrease in GAERS may be related to the onset of absence seizures or may be related to neurogenesis of absence epilepsy. (C) 2016 ISDN. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.ijdevneu.2016.12.001
dc.identifier.eissn1873-474X
dc.identifier.issn0736-5748
dc.identifier.pubmed27939427
dc.identifier.urihttps://hdl.handle.net/11424/234418
dc.identifier.wosWOS:000395600200005
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGAMMA-HYDROXYBUTYRATE MODEL
dc.subjectWAVE DISCHARGES
dc.subjectEPILEPSY RATS
dc.subjectALZHEIMERS-DISEASE
dc.subjectSPONTANEOUS SPIKE
dc.subjectCELL COUNTS
dc.subjectSEIZURES
dc.subjectMECHANISMS
dc.subjectSYSTEM
dc.subjectCORTEX
dc.titleA developmental study of glutamatergic neuron populations in the ventrobasal and the lateral geniculate nucleus of the thalamus: Comparing Genetic Absence Rats from Strasbourg (GAERS) and normal control wistar rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id6a148541-2b06-47f8-9f58-5b43aecbc0c0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ2
oaire.citation.endPage41
oaire.citation.startPage35
oaire.citation.titleINTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
oaire.citation.volume56
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

Files

Collections

Research Outputs