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11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease

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dc.contributor.authorAtalar, Fatmahan
dc.contributor.authorVural, Burçak
dc.contributor.authorÇiftci, Çavlan
dc.contributor.authorDemirkan, Ayşe
dc.contributor.authorAkan, Gökçe
dc.contributor.authorSüsleyici Duman, Belgin
dc.contributor.authorBüyükdevrim, Ahmet Sevim
dc.contributor.authorIDhttps://orcid.org/0000-0003-2426-6412en_US
dc.contributor.departmentMarmara Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.date.accessioned2020-12-08T11:40:10Z
dc.date.available2020-12-08T11:40:10Z
dc.date.issued2012
dc.description.abstract11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) activity and mRNA levels are increased in visceral and subcutaneous adipose tissues of metabolic syndrome subjects. We analyzed 11β-HSD-1 expression in human epicardial adipose (EA) and ascending aorta (AA) tissues of metabolic syndrome patients and examined their contribution to the development of coronary atherosclerosis. The 11β-HSD-1 expression was evaluated by qRT-PCR in EA and AA tissues of 20 metabolic syndrome patients with coronary artery disease (metabolic syndrome group) and 10 non-metabolic syndrome patients without coronary artery disease (controls). 11β-HSD-1 expression was increased in EA and AA tissues of the metabolic syndrome group (4.1- and 5.5-fold, respectively). A significant positive correlation was found between 11β-HSD-1 expression in EA tissue and waist hip ratio and 11β-HSD-1 expression in AA tissue and body mass index, while a negative correlation was found between 11β-HSD-1 expression in EA tissue and HDL. Expression of CD68, a macrophage marker, was significantly increased in both tissues of the metabolic syndrome group; it was 2-fold higher in AA tissue compared to EA tissue in the metabolic syndrome group. Our findings of increased expression of 11β-HSD-1 and CD68 in AA tissue of the metabolic syndrome group lead us to suggest that they contribute to coronary atherosclerosis in metabolic syndrome. This positive correlation between obesity markers and 11β-HSD-1 in AA and EA tissues strengthens the evidence that 11β-HSD-1 has a role in metabolic syndrome. To the best of our knowledge, this is the first report showing 11β-HSD-1 and CD68 expression in AA tissue of metabolic syndrome patients. We suggest that there is tissue-specific expression of 11β-HSD-1 in metabolic syndrome and associated cardiovascular disorders.en_US
dc.identifier.citationAtalar F, Vural B, Ciftci C, Demirkan A, Akan G, Susleyici-Duman B, Gunay D, Akpınar B, Sagbas E, Ozbek U, Buyukdevrim AS.11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease. Genetics and Molecular Research. (2012); 11(3): 3122 - 3132. doi: 10.4238/2012.August.31.10en_US
dc.identifier.endpage3132en_US
dc.identifier.issue3en_US
dc.identifier.startpage3122en_US
dc.identifier.urihttps://kutuphane.marmara.edu.tr/dosya/kutuphane/form-files//382//1584104162.pdfen_US
dc.identifier.urihttp://hdl.handle.net/11424/120752
dc.identifier.volume11en_US
dc.language.isoengen_US
dc.relation.journalGenetics and Molecular Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject11β-hydroxysteroid dehydrogenase type 1en_US
dc.subjectAscending aortaen_US
dc.subjectGlucocorticoidsen_US
dc.subjectEpicardial adipose tissueen_US
dc.subjectMetabolic syndromeen_US
dc.subjectCoronary artery diseaseen_US
dc.title11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery diseaseen_US
dc.typearticleen_US
dspace.entity.typePublication
local.import.packageSS40

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