Publication:
Chard (Beta vulgaris var. cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Simple item page
dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorsOztay, Fusun; Sacan, Ozlem; Kayalar, Ozgecan; Bolkent, Sehnaz; Ipci, Yesim; Kabasakal, Levent; Sener, Goksel; Yanardag, Refiye
dc.date.accessioned2022-03-13T12:48:46Z
dc.date.available2022-03-13T12:48:46Z
dc.date.issued2015
dc.description.abstractContext: Chard is used as an antidiabetic agent by the diabetic patients in Turkey. Objective: The effect of chard extract [Beta vulgaris L. var. cicla (Chenopodiaceae)] on the antioxidant system and the expression of surfactant-associated proteins (SP) in the lungs of hyperglycemic rats were examined. Materials and methods: Hyperglycemia was induced by a single dose of streptozotocin (60 mg/kg) provided intraperitoneally. Fourteen days after the rats were rendered hyperglycemic, the chard (2 g/kg/d), insulin (6 U/kg/d), and chard plus insulin (as mentioned above) were administered to rats for 45 d. On day 60, rats' lungs were removed. Oxidative stress parameters and SP expression were assayed. Results: The lungs of hyperglycemic rats were characterized by the induced lipid and protein oxidation, elevated myeloperoxidase and xanthine oxidase activities, decreased glutathione levels, and reduced tissue factor and antioxidant enzymes activities (catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase). Chard treatment alone and chard treatment combined with insulin were capable of achieving a regression of pulmonary oxidative stress, by inhibiting lipid and protein oxidation, and restoring the antioxidant system of hyperglycemic rats. SP-A expressions were significantly unchanged in all groups, whereas pro-SP-C and SP-D expressions were reduced in hyperglycemic rats. Pro-SP-C and SP-D levels were increased by chard and insulin administrations alone and combined in hyperglycemic rats. Discussion and conclusion: All treatments have a positive effect on the surfactant and antioxidant systems of the lungs of hyperglycemic rats. The best therapeutic effect was provided by treatment with chard extract alone in the compensation of hyperglycemic symptoms.
dc.identifier.doi10.3109/13880209.2014.997252
dc.identifier.eissn1744-5116
dc.identifier.issn1388-0209
dc.identifier.pubmed25880138
dc.identifier.urihttps://hdl.handle.net/11424/238239
dc.identifier.wosWOS:000361338900012
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofPHARMACEUTICAL BIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntidiabetic plant
dc.subjectpro-SP-C
dc.subjectpulmonary antioxidant system
dc.subjectSP-A
dc.subjectSP-D
dc.subjectOXIDASE INHIBITORY-ACTIVITY
dc.subjectLIPID-PEROXIDATION
dc.subjectDIABETIC-RATS
dc.subjectANTIOXIDANT ENZYMES
dc.subjectII PNEUMOCYTES
dc.subjectKAPPA-B
dc.subjectTISSUE
dc.subjectLIVER
dc.subjectDAMAGE
dc.subjectINJURY
dc.titleChard (Beta vulgaris var. cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs
dc.typearticle
dspace.entity.typePublication
local.avesis.id303062e6-97c4-4f08-b404-5eeb6eb0334a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage1646
oaire.citation.issue11
oaire.citation.startPage1639
oaire.citation.titlePHARMACEUTICAL BIOLOGY
oaire.citation.volume53
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublication.latestForDiscovery2fd85a89-446e-49e1-98c9-d20b11a1a2b5

Files

Collections

Research Outputs