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The diagnostic value of soluble urokinase plasminogen activator receptor compared with C-reactive protein and procalcitonin in children with febrile neutropenia

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dc.contributor.authorKOÇ, AHMET
dc.contributor.authorsSirinoglu, Melis; Soysal, Ahmet; Karaaslan, Ayse; Kadayifci, Eda Kepenekli; Cinel, Ismail; Koc, Ahmet; Tokuc, Gulnur; Yaman, Ali; Haklar, Goncagul; Sirikci, Onder; Turan, Serap; Gelmez, Gulsen Altinkanat; Soyletir, Guner; Bakir, Mustafa
dc.date.accessioned2022-03-12T20:27:38Z
dc.date.available2022-03-12T20:27:38Z
dc.date.issued2016
dc.description.abstractThe aim of the present study was to determine the diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) in pediatric patients with febrile neutropenia. A prospective case-control study was performed. Patients included 29 children with febrile neutropenia (FN) and 27 control subjects without any infection or immunosuppressive condition. Blood samples were obtained on the day of admission and on the 4th to 7th days of the hospital stay. The median (minimum-maximum) serum levels of suPAR obtained on the first day of the admission were 2.08 (0.93-9.42) and 2.22 (1.08-5.13) ng/mL for the FN group and the control group, respectively. The median serum levels of suPAR in the FN and control groups were not significantly different (P=.053). The mean serum suPAR level was significantly higher in nonsurvivors than in survivors in the FN group (P<.05). In the FN group, the area under the receiver operating characteristics curve (AUCROC) for suPAR was 0.546, but no optimum cutoff value, sensitivity, specificity, negative predictive value (NPV), or positive predictive value (PPV) was obtained. We conclude that suPAR is not useful as a diagnostic biomarker in children with febrile neutropenia; however, persistent high serum suPAR level may predict mortality in FN in children.
dc.identifier.doi10.3109/08880018.2016.1155100
dc.identifier.eissn1521-0669
dc.identifier.issn0888-0018
dc.identifier.pubmed27057782
dc.identifier.urihttps://hdl.handle.net/11424/233740
dc.identifier.wosWOS:000378742200007
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofPEDIATRIC HEMATOLOGY AND ONCOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChildren
dc.subjectfebril neutropenia
dc.subjectsoluble urokinase plasminogen activator receptor
dc.subjectSERUM-LEVELS
dc.subjectCEREBROSPINAL-FLUID
dc.subjectPLASMA
dc.subjectSUPAR
dc.subjectCANCER
dc.subjectMARKERS
dc.subjectMALARIA
dc.subjectLEVEL
dc.subjectUPAR
dc.titleThe diagnostic value of soluble urokinase plasminogen activator receptor compared with C-reactive protein and procalcitonin in children with febrile neutropenia
dc.typearticle
dspace.entity.typePublication
local.avesis.id3b3e7bd9-5f60-4ab8-b438-0226f4aaef60
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ3
oaire.citation.endPage208
oaire.citation.issue3
oaire.citation.startPage200
oaire.citation.titlePEDIATRIC HEMATOLOGY AND ONCOLOGY
oaire.citation.volume33
relation.isAuthorOfPublication41bfa1f1-f3ed-4d4b-9e02-902fd20bc830
relation.isAuthorOfPublication.latestForDiscovery41bfa1f1-f3ed-4d4b-9e02-902fd20bc830

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