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Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions

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dc.contributor.authorÇİNÇİN, AHMET ALTUĞ
dc.contributor.authorsSunbul, Murat; Cincin, Altug; Bozbay, Mehmet; Mammadov, Ceyhun; Atas, Halil; Ozsenel, Ekmel Burak; Sari, Ibrahim; Basaran, Yelda
dc.date.accessioned2022-03-14T08:16:18Z
dc.date.available2022-03-14T08:16:18Z
dc.date.issued2016
dc.description.abstractObjective: Arterial stiffness parameters including pulse wave velocity (PWV) and augmentation index (AIx) are associated with increased risk of cardiovascular disease. A close relationship has been demonstrated between vitamin D deficiency and cardiovascular disease. The aim of the present study was to investigate effects of vitamin D deficiency and supplementation on arterial stiffness parameters in patients with normal cardiac functions. Methods: Study population consisted of 45 patients with vitamin D deficiency and normal cardiac functions. Median age (interquartile range) was 45.0 (12.00) years, and 33 patients were female. Patients were treated with oral administration of vitamin D3. Arterial stiffness parameters were evaluated using Mobil-O-Graph arteriograph system, which detected signals from the brachial artery before and after treatment. Results: Vitamin D levels significantly increased after treatment (9.0 [6.00] nmol/L vs 29.0 [11.50] nmol/L, p<0.001). No significant difference was observed among conventional echocardiographic parameters before or after treatment. Post-treatment PVW and AIx were significantly lower than baseline measurements (6.8 [1.55] m/s vs 6.4 [1.30] m/s, p<0.001 and 23.0 [22.00]% vs 31.0 [14.50]%, p<0.001, respectively). Baseline vitamin D levels significantly correlated with PWV (r=-0.352, p=0.018). Post-treatment vitamin D levels also significantly correlated with post-treatment PWV (r=-0.442, p=0.002) and AIx (r=-0.419, p=0.004). Multivariate linear regression analysis revealed no independent predictor of baseline log-transformed PWV. Conclusion: Vitamin D supplementation has beneficial effects on arterial stiffness. Arterial stiffness parameters may aid in the assessment of cardiovascular risk in patients with vitamin D deficiency.
dc.identifier.doi10.5543/tkda.2015.93237
dc.identifier.issn1016-5169
dc.identifier.pubmed27372612
dc.identifier.urihttps://hdl.handle.net/11424/241369
dc.identifier.wosWOS:000380166800002
dc.language.isoeng
dc.publisherAVES
dc.relation.ispartofTURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectArterial stiffness
dc.subjectaugmentation index
dc.subjectcardiovascular risk
dc.subjectpulse wave velocity
dc.subjectvitamin D
dc.subjectOSCILLOMETRIC METHOD
dc.subjectHEMODYNAMICS
dc.subjectPREVENTION
dc.subjectDISEASE
dc.titleArterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions
dc.typearticle
dspace.entity.typePublication
local.avesis.id66962b6d-538c-4b11-81aa-f1c2f45086f8
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages8
oaire.citation.endPage288
oaire.citation.issue4
oaire.citation.startPage281
oaire.citation.titleTURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
oaire.citation.volume44
relation.isAuthorOfPublication54255a29-54c0-43de-8bc5-39d805d1296a
relation.isAuthorOfPublication.latestForDiscovery54255a29-54c0-43de-8bc5-39d805d1296a

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