Publication:
Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer

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2013

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TAYLOR & FRANCIS LTD

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Abstract

Context: TK1 found to be elevated biomarker in many solid cancers. Objectives: The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC. Methods: The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA method. Results: Patients with a bTK1 level > 156 Du L-1 had significantly shorter survival. TK1 level showed a strong correlation with primary tumor SUVmax. Discussion and conclusion: The magnitude of maximum fluorodeoxyglucose uptake in primary tumors and the serum TK1 level in patients with metastatic NSCLC were found to be independent prognostic predictors of overall survival.

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Thymidine kinase 1(TK1), non small cell lung cancer, DG uptake, prognosis, BREAST-CANCER, MARKER, PROLIFERATION, ASSOCIATION, DEGRADATION, RECURRENCE, LYMPHOMA, SURGERY, RISK

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https://hdl.handle.net/11424/231407

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