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Cost and length of hospital stay for healthcare facility-onset clostridioides difficile infection in pediatric wards: a prospective cohort analysis

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dc.contributor.authorKEPENEKLİ KADAYİFCİ, EDA
dc.contributor.authorsDemir S. O., KEPENEKLİ KADAYİFCİ E., Akkoc G., Yakut N., Soysal A.
dc.date.accessioned2023-07-25T08:28:01Z
dc.date.available2023-07-25T08:28:01Z
dc.date.issued2021-11-01
dc.description.abstractBackground. Clostridioides difficile (C. difficile) is a well-known causative agent of healthcare associated infection, it increases medical cost besides increasing morbidity and mortality. This study was conducted to determine the incidence, and economic burden of healthcare facility-onset C. difficile infection (HO-CDI) in children. Methods. Data was acquired with a prospective cohort study conducted in pediatric wards of a tertiary university hospital between August 2015 to August 2016. The HO-CDI was defined as diarrhea that began after 48 hours of admission with a positive cytotoxic stool assay for the presence of toxin A and/or B of C. difficile. Results. In the 3172 admissions in one year, 212 (7%) healthcare associated diarrhea (HAD) episodes were observed, in 25 (12%) of them C. difficile was identified in which 6 (25%) cases <2-year-old. The incidence of HOCDI was estimated as 8.8/10,000 patient-days. Cases with HO-CDI (n=19) were compared with cases with nonCDI-HAD (n=102); the presence of one of the risk factors for CDI increased the risk for HO-CDI (5,05; 95% Cl: 1.10-23.05; P 0,037), the median length of stay (LOS) attributable HO-CDI was 7 days (IQR,5-10) per admission, whereas for non-CDI-HAD was 2 days (IQR,0-4) (p=0.036). General hospitalization costs in the two groups were similar, specifically estimated costs attributable to HO-CDI and non-CID-HAD were $294.0 and $137.0 per Conclusion. Although in children the incidence of HO-CDI is increasing, its clinical manifestation is still milder and effective infection control measures with antibiotic stewardship can limit related morbidly, mortality, LOS, and cost.
dc.identifier.citationDemir S. O., KEPENEKLİ KADAYİFCİ E., Akkoc G., Yakut N., Soysal A., "Cost and length of hospital stay for healthcare facility-onset Clostridioides Difficile infection in pediatric wards: a prospective cohort analysis", TURKISH JOURNAL OF PEDIATRICS, cilt.63, sa.6, ss.1004-1011, 2021
dc.identifier.doi10.24953/turkjped.2021.06.008
dc.identifier.endpage1011
dc.identifier.issn0041-4301
dc.identifier.issue6
dc.identifier.startpage1004
dc.identifier.urihttps://www.turkishjournalpediatrics.org/uploads/pdf_TJP_2378.pdf
dc.identifier.urihttps://hdl.handle.net/11424/291535
dc.identifier.volume63
dc.language.isoeng
dc.relation.ispartofTURKISH JOURNAL OF PEDIATRICS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectChild Health and Diseases
dc.subjectHealth Sciences
dc.subjectPEDİATRİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPEDIATRICS
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectPediatri
dc.subjectPediatri, Perinatoloji ve Çocuk Sağlığı
dc.subjectPediatrics
dc.subjectPediatrics, Perinatology and Child Health
dc.subjecthealth-care
dc.subjectHO-CDI
dc.subjectC
dc.subjectdifficile
dc.subjectcost
dc.subjectpediatric
dc.subjectRISK-FACTORS
dc.subjectCHILDREN
dc.subjectBURDEN
dc.subjectCOLONIZATION
dc.subjectDISEASE
dc.subjecthealth-care
dc.subjectHO-CDI
dc.subjectC. difficile
dc.subjectcost
dc.subjectpediatric
dc.titleCost and length of hospital stay for healthcare facility-onset clostridioides difficile infection in pediatric wards: a prospective cohort analysis
dc.typearticle
dspace.entity.typePublication
local.avesis.idd724a7b8-f2e0-45c6-93c8-363be8db1f0a
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
relation.isAuthorOfPublicationb2936619-4301-4864-bd7e-10de0b997be0
relation.isAuthorOfPublication.latestForDiscoveryb2936619-4301-4864-bd7e-10de0b997be0

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