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3D bio-printing of levan/polycaprolactone/gelatin blends for bone tissue engineering: Characterization of the cellular behavior

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dc.contributor.authorİNAN, AHMET TALAT
dc.contributor.authorsDuymaz, Busra Tugce; Erdiler, Fatma Betul; Alan, Tugba; Aydogdu, Mehmet Onur; Inan, Ahmet Talat; Ekren, Nazmi; Uzun, Muhammet; Sahin, Yesim Muge; Bulus, Erdi; Oktar, Faik Nuzhet; Selvi, Sinem Selvin; ToksoyOner, Ebru; Kilic, Osman; Bostan, Muge Sennaroglu; Eroglu, Mehmet Sayip; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:38:31Z
dc.date.available2022-03-12T22:38:31Z
dc.date.issued2019
dc.description.abstractPoly(epsilon-caprolactone) (PCL), gelatin (GT) and different concentrations of low molecular weight Halomonas levan (HLh) were combined and examined to develop physical networks serving as tissue scaffolds to promote cell adhesion for biocompatibility. Three-dimensional bioprinting technique (3D bioprinting) was employed during manufacturing the test samples and their comprehensive characterization was performed to investigate the physicochemical properties and biocompatibility. Physical properties of the printing materials such as viscosity, surface tension, and density were measured to determine optimal parameters for 3D bioprinting. The scanning electron microscope (SEM) was used to observe the morphological structure of scaffolds. Fourier-Transform Infrared Spectroscopy (FT-IR) and differential scanning calorimetry (DSC) were used to identify the interactions between the components. In-vitro cell culture assays using standard human osteoblast (Hob) cells showed increased biocompatibility of the printing materials with increasing HLh content. Thus, the formulations including the HLh are expected to be a good candidate for the production of 3D printed materials.
dc.identifier.doi10.1016/j.eurpolymj.2019.08.015
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.urihttps://hdl.handle.net/11424/235657
dc.identifier.wosWOS:000489191900049
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofEUROPEAN POLYMER JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHalomonas levan
dc.subject3D printing
dc.subjectTissue engineering
dc.subjectSCAFFOLDS
dc.subjectGELATIN
dc.subjectLEVAN
dc.title3D bio-printing of levan/polycaprolactone/gelatin blends for bone tissue engineering: Characterization of the cellular behavior
dc.typearticle
dspace.entity.typePublication
local.avesis.idbf74e9dc-7f10-41dd-9232-26b4acb168ed
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages12
local.journal.quartileQ1
oaire.citation.endPage437
oaire.citation.startPage426
oaire.citation.titleEUROPEAN POLYMER JOURNAL
oaire.citation.volume119
relation.isAuthorOfPublication523a8f6a-88ba-46c7-9bc5-8bbab957b2c5
relation.isAuthorOfPublication.latestForDiscovery523a8f6a-88ba-46c7-9bc5-8bbab957b2c5

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