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Synthesis and Antibacterial Activity of New Chiral Aminoalcohol and Benzimidazole Hybrids

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dc.contributor.authorABDURRAHMANOĞLU, SUZAN
dc.contributor.authorsCicek, Ilknur; Tunc, Turgay; Ogutcu, Hatice; Abdurrahmanoglu, Suzan; Gunel, Aslihan; Demirel, Nadir
dc.date.accessioned2022-03-12T22:41:56Z
dc.date.available2022-03-12T22:41:56Z
dc.date.issued2020
dc.description.abstractNew chiral aminoalcohol-benzimidazole hybrids have been synthesized from commercially available aminoalcohols [S(+)-Phenylglycinol, S(-)- Phenylalaninol and S(+)- Leuicinol] and 2-(chloromethyl)-N-tosyl-1-H-benzimidazole. The synthesized compound were characterized by IR, NMR, and LC-MS analysis. The antibacterial properties of aminoalcohol-benzimidazole hybrid molecules 4 a, 4 b, and 4 c were investigated against both gram (+ve) and gram (-ve) bacterial pathogens by the well-diffusion method using several standarts. The cell-based biological experiment was consistent with in silico studies. Furthermore, in silico studies revealed that all synthesized compounds could be suggested as potential drugs for inhibition of both peptide deformylase for bacteria and sterol 14 alpha-demethylase for yeast.
dc.identifier.doi10.1002/slct.202000355
dc.identifier.issn2365-6549
dc.identifier.urihttps://hdl.handle.net/11424/236182
dc.identifier.wosWOS:000528045700036
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofCHEMISTRYSELECT
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBenzimidazole
dc.subjectAntibacterial Agent
dc.subjectAminoalcohol
dc.subjectPDF inhibitor
dc.subjectMolecular docking
dc.subjectPEPTIDE DEFORMYLASE
dc.subjectDERIVATIVES
dc.subjectPOTENT
dc.subjectDISCOVERY
dc.subjectDESIGN
dc.subjectBACTEREMIA
dc.subjectSERIES
dc.titleSynthesis and Antibacterial Activity of New Chiral Aminoalcohol and Benzimidazole Hybrids
dc.typearticle
dspace.entity.typePublication
local.avesis.idb8a6108b-c5af-4b96-b3b6-2fb1e7b3634f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
local.journal.quartileQ3
oaire.citation.endPage4654
oaire.citation.issue15
oaire.citation.startPage4650
oaire.citation.titleCHEMISTRYSELECT
oaire.citation.volume5
relation.isAuthorOfPublicationc4f5249d-7638-47df-be54-950af42ffa85
relation.isAuthorOfPublication.latestForDiscoveryc4f5249d-7638-47df-be54-950af42ffa85

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