Publication:
Punica Granatum Peel Extract Protects Against Ionizing Radiation-Induced Enteritis And Leukocyte Apoptosis In Rats

Simple item page
dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsToklu, Hale Z.; Sehirli, Oezer; Ozyurt, Hazan; Mayadagli, A. Alpaslan; Eksioglu-Demiralp, Emel; Cetinel, Sule; Sahin, Huelya; Yegen, Berrak C.; Dumlu, Melek Ulusoylu; Gokmen, Vural; Sener, Goeksel
dc.date.accessioned2022-03-14T09:12:17Z
dc.date.available2022-03-14T09:12:17Z
dc.date.issued2009
dc.description.abstractApoptosis/Cytokine/Enteritis/Ileum/Irradiation/Punica granatum/Pomegranate/Radioprotective. Radiation-induced enteritis is a well-recognized sequel of therapeutic irradiation. Therefore we examined the radioprotective properties of Punica granatum peel extract (PPE) on the oxidative damage in the ileum. Rats were exposed to a single whole-body X-ray irradiation of 800 cGy. Irradiated rats were pretreated orally with saline or PPE (50 mg/kg/day) for 10 days before irradiation and the following 10 days, while control rats received saline or PPE but no irradiation. Then plasma and ileum samples were obtained. Irradiation caused a decrease in glutathione and total antioxidant capacity, which was accompanied by increases in malondialdehyde levels, myeloperoxidase activity, collagen content of the tissue with a concomitant increase 8-hydroxy-2'-deoxyguanosine (an index of oxidative DNA damage). Similarly, pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) and lactate dehydrogenase were elevated in irradiated groups as compared to control. PPE treatment reversed all these biochemical indices, as well as histopathological alterations induced by irradiation. Furthermore, flow cytometric measurements revealed that leukocyte apoptosis and cell death were increased in irradiated animals, while PPE reversed these effects. PPE supplementation reduced oxidative damage in the ileal tissues, probably by a mechanism that is associated with the decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. Adjuvant therapy of PPE may have a potential to support a Successful radiotherapy by protecting against radiation-induced enteritis.
dc.identifier.doi10.1269/jrr.08126
dc.identifier.eissn1349-9157
dc.identifier.issn0449-3060
dc.identifier.pubmed19478462
dc.identifier.urihttps://hdl.handle.net/11424/242758
dc.identifier.wosWOS:000268817400007
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS
dc.relation.ispartofJOURNAL OF RADIATION RESEARCH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPROSTATE-CANCER
dc.subjectOXIDATIVE STRESS
dc.subjectPOMEGRANATE
dc.subjectANTIOXIDANTS
dc.subjectINFLAMMATION
dc.subjectIRRADIATION
dc.subjectL.
dc.subjectCHEMOPREVENTION
dc.subjectDYSFUNCTION
dc.subjectINJURY
dc.titlePunica Granatum Peel Extract Protects Against Ionizing Radiation-Induced Enteritis And Leukocyte Apoptosis In Rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idb16cb574-28bd-453f-9a05-c482e59e17d9
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage353
oaire.citation.issue4
oaire.citation.startPage345
oaire.citation.titleJOURNAL OF RADIATION RESEARCH
oaire.citation.volume50
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Toklu et al. - 2009 - Punica Granatum Peel Extract Protects Against Ioni.pdf
Size:
961.95 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs