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Neurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease

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dc.contributor.authorÇERMAN, EREN
dc.contributor.authorsEraslan, Muhsin; Cerman, Eren; Cekic, Osman; Balci, Sevcan; Dericioglu, Volkan; Sahin, Ozlem; Suer, Devran; Chabou, Biman; Tuncer Elmaci, Emine Nese
dc.date.accessioned2022-04-25T00:10:53Z
dc.date.available2022-04-25T00:10:53Z
dc.date.issued2015
dc.description.abstractBackground/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. Materials and methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients. Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG and AD patients when compared to the control subjects (P = 0.004, P = 0.006, P < 0.001, respectively). The statistical evaluation showed no difference in any RNFL or GCC parameters between the AD and NTG groups (P > 0.05). There was a negative correlation between disease duration and average RNFL and GCC thicknesses (r = -0.350, P = 0.027 and r = -0.471, P = 0.002, respectively) and a positive correlation between duration and GLV (r = 0.427, P = 0.006) in the AD group. Conclusion: The average RNFL thickness, GCC thickness, and GLV rates may help in the diagnosis of AD as an additional examination and may provide some important clues about the duration of the disease.
dc.identifier.doi10.3906/sag-1406-145
dc.identifier.eissn1303-6165
dc.identifier.issn1300-0144
dc.identifier.pubmed26738355
dc.identifier.urihttps://hdl.handle.net/11424/263792
dc.identifier.wosWOS:000362526300020
dc.languageeng
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOptical coherence tomography
dc.subjectAlzheimer disease
dc.subjectnormal-tension glaucoma
dc.subjectretinal nerve fiber layer
dc.subjectganglion cell complex
dc.subjectOPEN-ANGLE GLAUCOMA
dc.subjectRETINAL VESSEL DIAMETER
dc.subjectGANGLION-CELL
dc.subjectFIBER LAYER
dc.subjectCOGNITIVE IMPAIRMENT
dc.subjectTHICKNESS
dc.subjectRISK
dc.subjectABNORMALITIES
dc.subjectDEGENERATION
dc.subjectHYPOTHESIS
dc.titleNeurodegeneration in ocular and central nervous systems: optical coherence tomography study in normal-tension glaucoma and Alzheimer disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id38d60cb4-8b30-4679-9ab2-679785584a0e
local.import.packageSS39
local.indexed.atWOS
local.journal.numberofpages9
oaire.citation.endPage1114
oaire.citation.issue5
oaire.citation.startPage1106
oaire.citation.titleTURKISH JOURNAL OF MEDICAL SCIENCES
oaire.citation.volume45
relation.isAuthorOfPublication94b7eabe-feca-456f-8edb-62cf4425293a
relation.isAuthorOfPublication.latestForDiscovery94b7eabe-feca-456f-8edb-62cf4425293a

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