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Bioactivity-guided isolation of anti-proliferative compounds from endemic Centaurea kilaea

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsSen, Ali; Turan, Suna Ozbas; Bitis, Leyla
dc.date.accessioned2022-03-14T08:17:50Z
dc.date.available2022-03-14T08:17:50Z
dc.date.issued2017-01-01
dc.description.abstractContext: The genus Centaurea L. (Asteraceae) is one of the largest genera in Turkey. Compounds and extracts obtained from different Centaurea species have significant anti-cancer activity against various cancer cell lines. Objective: To determine the anti-proliferative activity of isolates from the chloroform extract of C. kilaea Boiss. Materials and methods: Eleven compounds were isolated using column chromatography and preparative TLC from the chloroform extract of aerial parts of endemic C. kilaea. The structures of the isolated compounds were elucidated by various spectroscopic methods, including UV, H-1-NMR and C-13-NMR. Anti-proliferative activity of compounds (0.5-50 mu g/mL) were measured against one normal cell line (L-929, mouse fibroblast) and three human cancer cell lines (Hela, cervix carcinoma; MCF-7, breast carcinoma; PC-3, prostate carcinoma) using MTT assay. Results were expressed as IC50 values. Results: None of the 11 compounds displayed activity against L-929 and HeLa. Two of these compounds, cnicin and cirsimaritin, showed fairly strong activity against MCF-7 and PC-3 with IC50 values of 3.25 and 4.3 mu g/mL, respectively. Discussion and conclusion: This is the first report on cirsimaritin. Cirsimaritin and cnicin could serve as potential anti-cancer drug candidates against breast and prostate cancer, respectively.
dc.identifier.doi10.1080/13880209.2016.1255980
dc.identifier.eissn1744-5116
dc.identifier.issn1388-0209
dc.identifier.pubmed27938087
dc.identifier.urihttps://hdl.handle.net/11424/241466
dc.identifier.wosWOS:000390846600065
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofPHARMACEUTICAL BIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAsteraceae
dc.subjectbreast cancer
dc.subjectcnicin
dc.subjectcirsimaritin
dc.subjectprostate cancer
dc.subjectCHEMICAL-CONSTITUENTS
dc.subjectFLAVONOID AGLYCONES
dc.subjectANTIOXIDANT
dc.subjectEXTRACT
dc.subjectLEAVES
dc.titleBioactivity-guided isolation of anti-proliferative compounds from endemic Centaurea kilaea
dc.typearticle
dspace.entity.typePublication
local.avesis.id474c6ee0-0f44-47ce-9412-1ced387ec29e
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ2
oaire.citation.endPage546
oaire.citation.issue1
oaire.citation.startPage541
oaire.citation.titlePHARMACEUTICAL BIOLOGY
oaire.citation.volume55
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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