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The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings

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dc.contributor.authorGÜLÇEBİ İDRİZ OĞLU, MEDİNE
dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsYAVUZ M., Albayrak N., Ozgur M., Oglu M., Cavdar S., Onat F.
dc.date.accessioned2022-11-18T17:58:52Z
dc.date.available2022-11-18T17:58:52Z
dc.date.issued2019-11-01
dc.description.abstractCaffeine, a central nervous system stimulant, has been reported to modulate seizure activity in various studies. In this study the effects of caffeine exposure on the pentylenetetrazole (PTZ) induced seizure thresholds and seizure stages in the Wistar and genetic absence epilepsy model offsprings were examined. Adult female and male Wistar rats and genetic absence epilepsy rats from Strasbourg (GAERS) consumed caffeine dissolved in water (0.3 g/L) before conception, during the gestational periods and lactation period whereas control groups of each strain received tap water. All offsprings at postnatal day 30 (PN30) subjected to 70 mg/kg of PTZ were evaluated in terms of overall seizure stages, the latency to the first generalized seizure and the c-Fos protein activity in the brain regions of somatosensorial cortex (SSCx), reticular thalamic nucleus (Rt), ventrobasal thalamus (VB), centromedial nucleus (CM) and lateral geniculate nucleus (LGN). The Wistar caffeine group had significantly shorter latency to the first generalized seizure (1.53 +/- 0.49 min) comparing to the Wistar control offsprings (3.40 +/- 0.68 min). GAERS caffeine group (6.52 +/- 2.48 min) showed significantly longer latency comparing to Wistar caffeine group (1.53 +/- 0.49 min). Although statistically not significant, GAERS caffeine group showed a longer latency comparing to the GAERS control group (4.71 +/- 1.82 min). In all regions of SSCx, Rt, VB, CM and LGN, GAERS caffeine group had lower c-Fos protein expression comparing to the GAERS control group (p < 0.05). Wistar caffeine rats had lower expression of c-Fos protein comparing to the Wistar control group only in SSCx. In CM, GAERS rats expressed lower c-Fos protein comparing to the Wistar control (p < 0.05). In conclusion differential effects of caffeine in the seizure modulation may involve c-Fos protein activity-dependent protection mechanisms.
dc.identifier.citationYAVUZ M., Albayrak N., Ozgur M., Oglu M., Cavdar S., Onat F., "The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings", NEUROSCIENCE LETTERS, cilt.713, 2019
dc.identifier.doi10.1016/j.neulet.2019.134504
dc.identifier.issn0304-3940
dc.identifier.urihttps://hdl.handle.net/11424/283237
dc.identifier.volume713
dc.language.isoeng
dc.relation.ispartofNEUROSCIENCE LETTERS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectSİNİR BİLİMİ
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectNEUROSCIENCES
dc.subjectNEUROSCIENCE & BEHAVIOR
dc.subjectLife Sciences (LIFE)
dc.subjectDuyusal Sistemler
dc.subjectGelişimsel Sinirbilim
dc.subjectBilişsel Sinirbilim
dc.subjectHücresel ve Moleküler Sinirbilim
dc.subjectSinirbilim (çeşitli)
dc.subjectGenel Sinirbilim
dc.subjectİnsan Bilgisayar Etkileşimi
dc.subjectFizik Bilimleri
dc.subjectSensory Systems
dc.subjectDevelopmental Neuroscience
dc.subjectCognitive Neuroscience
dc.subjectCellular and Molecular Neuroscience
dc.subjectNeuroscience (miscellaneous)
dc.subjectGeneral Neuroscience
dc.subjectHuman-Computer Interaction
dc.subjectPhysical Sciences
dc.subjectPentylenetetrazole
dc.subjectGAERS
dc.subjectCaffeine
dc.subjectc-Fos protein
dc.subjectThalamus
dc.subjectSomatosensorial cortex
dc.subjectGENETIC ABSENCE EPILEPSY
dc.subjectFOS MESSENGER-RNA
dc.subjectC-FOS
dc.subjectSOMATOSENSORY CORTEX
dc.subjectGABA(A) RECEPTOR
dc.subjectWAVE DISCHARGES
dc.subjectTHALAMIC NUCLEI
dc.subjectEXPRESSION
dc.subjectRATS
dc.subjectSUSCEPTIBILITY
dc.titleThe effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings
dc.typearticle
dspace.entity.typePublication
local.avesis.id9e52ad0b-feb0-4cb0-9564-847288406554
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationbfae5034-1dff-487a-9d01-354aa598c973
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoverybfae5034-1dff-487a-9d01-354aa598c973

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