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Sıçanlarda whey proteini ile oluşturulan glutatyon önkoþullandırmasının karaciğer sıcak iskemi/reperfüzyon hasarında hem oksijenaz-1 sistemi üzerine etkisi

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2008-09-01

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Purpose: Oxygen radicals which are produced during reperfusion phase play a central role for hepatocellular damage during ischemia/reperfusion (I/R) injury. Antioxidant strategies appear a promising approach to prevent I/R injury. In the present study, the effect of glutathione (GSH) preconditioning established by whey protein feeding on hepatocellular injury markers was assessed in a rat hepatic normothermic I/R injury model. The interaction between intracellular GSH content and heme oxygenase-1 (HO-1) enzyme expression was also determined in order to understand the level of upgrading of HO-1 system in a high GSH content environment after preconditioning.

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Tıp, Cerrahi Tıp Bilimleri, Sağlık Bilimleri, Medicine, Surgery Medicine Sciences, Health Sciences, CERRAHİ, Klinik Tıp, Klinik Tıp (MED), SURGERY, CLINICAL MEDICINE, Clinical Medicine (MED), Cerrahi, Surgery, Liver, ischemia/reperfusion, whey, glutathione, heme oxygenase-1

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Manukyan M. N., Yavuz Y., Erbarut I., Ogunc A. V., Ataizi-Celikel Ç., Yalcin A. S., GÜLLÜOĞLU M. B., "The effect of glutathione preconditioning on heme oxygenase-1 system established by whey protein feeding on hepatocellular injury in a rat hepatic normothermic i/r injury model", TURKISH JOURNAL OF SURGERY, cilt.24, sa.3, ss.137-144, 2008

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https://hdl.handle.net/11424/285673

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