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Long-term clinical and angiographic follow-up results of the dual-layer flow diverter device (FRED) for the treatment of intracranial aneurysms in a multicenter study

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dc.contributor.authorBALTACIOĞLU, FEYYAZ
dc.contributor.authorsDinc, Hasan; Saatci, Isil; Oguz, Sukru; Baltacioglu, Feyyaz; Yildiz, Altan; Donmez, Halil; Belet, Umit; Onal, Baran; Andic, Cagatay; Koc, Osman; Kocak, Omer; Koroglu, Mert; Cetin, Mustafa; Cekirge, H. Saruhan
dc.date.accessioned2022-03-12T22:59:05Z
dc.date.available2022-03-12T22:59:05Z
dc.date.issued2021
dc.description.abstractPurpose Our aim was to determine the long-term safety and efficacy of the Flow Re-Direction Endoluminal Device (FRED) in this multicenter study with prospective design. Materials-method This study included 136 consecutive patients with 155 aneurysms treated between March 2013 and June 2016 in 10 centers. Twenty-two (16.2%) patients presented with rupture of the index aneurysm. Large/giant aneurysms comprised 1/3 of the cohort. Adjuvant coil use during the treatment was 15.5%. The effectiveness measure in the study was the percentage of aneurysms with stable occlusion at follow-up. Results Vascular imaging follow-up was performed at least once in 131/136 (96.3%) patients with 148/155 (95.5%) aneurysms up to 75 months (mean: 37.3 months; median: 36 months according to latest follow-up), and 102/155(65.8%) aneurysms in 90/136 (66.2%) patients had >= 24-month control. According to the latest controls, the overall stable occlusion rate was 91.9% (95% CI, 87.5 to 96.3%). Three out of 148 aneurysms with follow-up were retreated (2%, 95% CI 0.0 to 4.3%). Adverse events were noted in 19/136 (14%, 95% CI, 9 to 21%) patients with a morbidity of 1.5% (95% CI, 0.0 to 3.5%). Mortality was 1/136 (0.7%, 95% CI, 0.02 to 2.2%) and was unrelated to aneurysm treatment. In-stent stenosis (ISS) was detected in 10/131 of the patients with follow-up (7.6%, 95% CI; 3.1 to 12.2%), only one being symptomatic. No adverse events have occurred in any of the patients with follow-up after 24 months, except the one resulting from ISS. Conclusion In the treatment of cerebral aneurysms which were candidates for flow diversion technique, this study showed long-term efficacy of FRED with good safety and occlusion rates.
dc.identifier.doi10.1007/s00234-020-02627-1
dc.identifier.eissn1432-1920
dc.identifier.issn0028-3940
dc.identifier.pubmed33392735
dc.identifier.urihttps://hdl.handle.net/11424/237270
dc.identifier.wosWOS:000604485200005
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofNEURORADIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCerebral aneurysm
dc.subjectFlow diversion
dc.subjectEndovascular treatment
dc.subjectFlow Re-Direction Endoluminal device&#8201
dc.subject=&#8201
dc.subjectFRED
dc.subjectREDIRECTION ENDOLUMINAL DEVICE
dc.subjectPIPELINE EMBOLIZATION DEVICE
dc.subjectENDOVASCULAR TREATMENT
dc.subjectCEREBRAL ANEURYSMS
dc.subjectINITIAL-EXPERIENCE
dc.subjectARTERY ANEURYSMS
dc.subjectSAFETY
dc.subjectEFFICACY
dc.subjectSTENT
dc.titleLong-term clinical and angiographic follow-up results of the dual-layer flow diverter device (FRED) for the treatment of intracranial aneurysms in a multicenter study
dc.typearticle
dspace.entity.typePublication
local.avesis.ide2066b3a-7326-4d80-a93c-9052455bffcc
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage952
oaire.citation.issue6
oaire.citation.startPage943
oaire.citation.titleNEURORADIOLOGY
oaire.citation.volume63
relation.isAuthorOfPublication14b6381a-4f6e-4ff9-92f6-842a481bc163
relation.isAuthorOfPublication.latestForDiscovery14b6381a-4f6e-4ff9-92f6-842a481bc163

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